MacrophagesProteoglycanInter-α-trypsin Inhibitor Heavy Chain 2TNF-stimulated Gene-6Amyloid Precursor-like Protein 2HyaluronanVersicanBackground: Macrophage differentiation is accompanied by expression of unique extracellular matrix molecules. Results: Monocyte-to-macrophage transition involves selective expression ...
These results suggested that MMD modulates TNF-α and NO production in macrophages, and this process might involves Erk or Akt. 展开 关键词: Monocyte to macrophage differentiation-associated (MMD Macrophages PAQR family Erk Akt DOI: 10.1007/s11033-011-1370-5 ...
serum﹊nduced differentiationHLA class II antigensinterferonCells of the mononuclear phagocyte system arise from circulating blood monocytes. Upon emigration from the vasculature, monocytes differentiate into macrophages, a process that monocytes similarly undergo in vitro. We have established primary cultures...
macrophages reside in all layers of the small intestine and colon; the lamina propria, muscularis externa, and serosa. Macrophages in the muscularis and serosa interact with enteric neurons to control intestinal motility but also provide tissue protection during injury1. The largest...
IFN-γ Drives Human Monocyte Differentiation into Highly Proinflammatory Macrophages That Resemble a Phenotype Relevant to Psoriasis As key cells of the immune system, macrophages coordinate the activation and regulation of the immune response. Macrophages present a complex phenotype that can vary from hom...
OBJECTIVE: Our purpose was to examine RU 486 and related compounds on monocyte to macrophage differentiation through scavenger receptors and cellular adhesion. STUDY DESIGN: Human monocytes were isolated, cultured, and treated with dexamethasone, levonorgestrel, RU 486, and other structurally related compo...
A differentiation process of monocytoid THP-1 cells was also augmented by EM. These results indicate that EM promotes differentiation of human monocyte-macrophage lineage, altering their functions. 展开 关键词: Monocytes Cells, Cultured Tumor Cells, Cultured Macrophages Humans Leukemia, Monocytic, Acute...
Human peripheral CD14+monocytes have been known to differentiate into monocyte-derived macrophages (MDMs) or dendritic cells (MoDCs) upon suitable stimulation. However, the key intracellular molecule(s) associated with their differentiation towards specific cell types was(were) not fully understood. This...
derived macrophages as tissue rheostats and their detrimentalhyperactivation. Environmental factors that dictate local monocyte differentiation remain incompletely understood. Definition of the latter could aid our general understanding ofin vivomonocyte functions and their relation to inflammatory disorders. In ...
6) monocyte-derived macrophages 单核源巨噬细胞 1. Objective To investigate the clinical significance of matrix metalloproteinase-9 (MMP-9) and tissue factor (TF) secreted by cultured monocyte-derived macrophages (HMDM) from patients with coronary heart disease (CHD) in vitro, and to evaluate ...