The differences observed in macrophages as compared to monocytes can be explained by 1) p38/ERKs-independent phosphorylation of PAF-AH (II) and 2) appearance of plasma PAF-AH in the course of macrophage differentiation.doi:10.1096/fj.05-5059fjeLuigi Servillo...
Tumour-derived microvesicles (TMVs) are important players in tumour progression, modulating biological activity of immune cells e.g. lymphocytes, monocytes and macrophages. This phenomenon is particularly interesting in the progression of colon cancer, a
Monocytes and macrophages Systems analysis This article is cited by Discovery of Therapeutic Antibodies Targeting Complex Multi-Spanning Membrane Proteins Amberley D. Stephens Trevor Wilkinson BioDrugs(2024) Cross center single-cell RNA sequencing study of the immune microenvironment in rapid progressing mult...
Previous study strongly suggests that silicotic fibrosis is mediated by macrophages and their soluble mediators. The biochemical properties of the mediators involved in silicotic fibrosis, however, are as yet ill defined. The current study, therefore, determined whether human monocyte-macrophages treated...
Monocytes are the largest white blood cells of the immune system. Monocytes protect us from bacteria, fungi and viruses. Monocytes function by changing into macrophages and eating the foreign material, mounting parts of the germs on the outsides of themselves so that the other white blood cells...
of the TLRs that initiates the intracellular cascade2. The myeloid differentiation factor 88 (MyD88)-dependent pathway, which is used by all TLRs except for TLR3, leads to early activation of NFκB for inflammatory cytokine production, specially TNFα by monocytes/macrophages. Instead, viral ...
[29,30,31,33,34,35,39,64,65,66]. GCase, the enzyme encoded by the PD-genetic risk factorGBA, is important for the metabolic processes of scavenger cells such as monocytes and macrophages. Compared to previous works that performed unbiased transcriptomic analysis comparing PD and CTRL ...
Frangogiannis NG (2014) The inflammatory response in myocardial injury, repair, and remodelling.Nat Rev Cardiol11: 255–265 Go to Citation Crossref PubMed CAS Google Scholar Geissmann F, Manz MG, Jung S, Sieweke MH, Merad M, Ley K (2010) Development of monocytes, macrophages and dendritic...
In addition, the monocytes/ macrophages have reduced expression of HLA-DR and a strongly reduced capacity to respond to LPS in terms of proinflammatory mediator production (IL-1β. IL-6, IL-8, MIP-1α, TNF-α), NFKB activation, and tyrosine phosphorylation. Mechanistic studies reveal that ...
(over the range of 6.25, 12.5, 25 and 50 μg/mL), endocytosis of LL-37-FAM was slightly increased (data not shown), a result in contrast to the previously reported results for THP-1 differentiated macrophages or human monocyte derived macrophages (HMDMs) treated with LL-37 (Tang et al...