Tumour-derived microvesicles (TMVs) are important players in tumour progression, modulating biological activity of immune cells e.g. lymphocytes, monocytes and macrophages. This phenomenon is particularly interesting in the progression of colon cancer, a
The differences observed in macrophages as compared to monocytes can be explained by 1) p38/ERKs-independent phosphorylation of PAF-AH (II) and 2) appearance of plasma PAF-AH in the course of macrophage differentiation.doi:10.1096/fj.05-5059fjeLuigi Servillo...
Monocytes and macrophages, in turn, can regulate KSHV-infected cells in tumorigenesis and cytokine secretion, leading to the pro-tumour microenvironment. Further investigations into the viral regulation of monocytes and macrophages thus have potential to lead to the discovery of novel antitumour ...
Monocytes and macrophages Systems analysis This article is cited by A joint analysis of single cell transcriptomics and proteomics using transformer Yuanyuan Chen Xiaodan Fan Chaojie Wang npj Systems Biology and Applications(2025) Discovery of Therapeutic Antibodies Targeting Complex Multi-Spanning Membrane ...
In silico analyses predicted GRP78, which is constitutively expressed on monocytes and macrophages, to be a potential candidate receptor for SARS-CoV-2 virus entry. Methods Hospitalized COVID-19 patients were characterized regarding their pro-inflammatory state and cell surface GRP78 (csGRP78) ...
[29,30,31,33,34,35,39,64,65,66]. GCase, the enzyme encoded by the PD-genetic risk factorGBA, is important for the metabolic processes of scavenger cells such as monocytes and macrophages. Compared to previous works that performed unbiased transcriptomic analysis comparing PD and CTRL ...
We next tested if the increased availability and recruitment of Ly6Chimonocytes was required for HFHCD-accelerated tumor growth. First, we treated mice with a neutralizing anti-CD115 antibody, which has been shown to alter the differentiation of tumor-associated macrophages due to impaired CSF1/CSF...
and disease risk, and will be the topic of the following section. Finally, we place a particular emphasis on the growing evidence supporting a key role for microglia, and moreover, monocyte-derived macrophages in the physiological clearance of cerebral Aβ (see Fig.1), and we examine their ...
[8]. In the multiple low doses of streptozotocin model of diabetes galectin-3 deficient mice are relatively resistant to hyperglycemia. Islet inflammation is reduced and this is partly explained by a lower TNF expression of infiltrating macrophages[14]. Therefore, most of the data published so ...
Lair1−/− mice had reduced frequencies of Ly6C− monocytes, which were associated with altered proliferation and apoptosis of non-classical monocytes from bone marrow and altered heterogeneity of interstitial macrophages in lung. Myeloid-specific LAIR1 deficiency promoted metastatic growth in a ...