et al., Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model. Eur J Immunol 2010, 40, 443-448.Pils MC, Pisano F, Fasnacht N, Heinrich JM, Groebe L, Schippers A, Rozell B, Jack RS, Mu¨ ller W. 2010. Monocytes/macrophages and/or ...
In addition to patrolling monocytes, myeloid cells with a highly dendritic appearance were also described in the luminal aspect of the aorta, especially at sites prone to develop atherosclerosis, such as the aortic arch13,14. Despite their conspicuous location, the contribution of these myeloid ...
Human monocytes are integral to the innate immune response and pivotal in first-line defenses such as phagocytosis, cytokine and chemokine release, and antigen presentation1. Activation of monocytes is triggered by pattern recognition receptors (PRRs) that sense conserved pathogen-associated molecular patt...
Similarly, exosomes mediate the transfer of chemokine receptor CCR5 between monocytes and endothelial cells, playing a role in HIV-1 transmission [25]. In the nervous system, exosomes facilitate protein delivery, such as synaptotagmin 4, from presynaptic to postsynaptic cells [26]. The specificity ...
The combined induction of these L-arginine-catabolizing enzymes has been linked to an increased immunosuppressive capacity of monocytes/macrophages (Bronte et al., 2003), a feature which we recapitulated here for MHC-IIlo TAMs. Hence, lactate promotes the immunosuppressive capacity of pro-tumoral ...
A gating strategy was applied to dis- tinguish monocytes and granulocytes from lymphocytes and debris. The relative number of infected blood cells was expressed as the percentage of living cells post-infec- tion (p.i.) compared to the control sample with unin- fected cells. Additionally, the ...
Monocytes are unusual in their ability to transform into different kinds of cells based on the needs of the immune system. They consume invading cells and broadcast information about infections.Answer and Explanation: Monocytes are one of several different types of white blood cells. They are ...
Macrophages are recruited to the lung by SARS-CoV-2-infected cells expressing ACE2 [56]. The stronger inflammatory state described in circulating monocytes from men compared to women [24] suggests that senescent-like macrophages compound the inflammation induced by COVID-19 through the production of...
or target of action. For example, lymphokines are cytokines produced by activated lymphocytes, monokines are cytokines produced by monocytes or macrophages, chemokines are cytokines with chemotactic activity, and interleukins were initially named for their ability to mediate interactions between leukocytes....
Monocytes were enriched from PBMCs using MACS CD14 þ microbeads (Miltenyi). Monocytes were differentiated into macrophages (macrophages or GM-MF), by incubating the CD14 þ cells for 7 days in X-VIVO15 (Lonza), Pen/strep (Sigma-Aldrich), L-glutamine (Sigma-Aldrich) with 50 ng ml ...