Thus, monocytes and macrophages concurrently play important roles throughout the trimesters. Dysregulation of these cells may thus lead to pregnancy complications, such as pre-eclampsia and preterm labor. In this review, monocytes and macrophage subsets and their roles in normal and pathological ...
aare the most potent effector cells, followed by[translate] ainfection with Cryptococcus neoformans, despite[translate] aIn contrast, DCs possess fungicidal activity[translate] ainfections with most fungal pathogens, but[translate] amacrophages and monocytes are permissive for[translate]...
Lymph node cells from SJL mice immunized with guinea pig myelin basic protein proliferate in vitro to the same antigen. This proliferative response is abolished by depletion of macrophages-monocytes, but can be reconstituted by the addit... RM Mccarron,M Spatz,O Kempski,... - 《Journal of Im...
Successful tissue repair requires the activities of myeloid cells such as monocytes and macrophages that guide the progression of inflammation and healing outcome. Immunoregenerative materials leverage the function of endogenous immune cells to orchestrate complex mechanisms of repair; however, a deeper unde...
For instance, the loss of PTEN was found in prostate cancers with more infiltration of Gr-1 + CD11b + myeloid cells (immature myeloid cells, monocytes, and neutrophils) [30]. In a similar study, loss of PTEN was speculated to be one of the reasons of reduced CD8 + T ...
In addition to patrolling monocytes, myeloid cells with a highly dendritic appearance were also described in the luminal aspect of the aorta, especially at sites prone to develop atherosclerosis, such as the aortic arch13,14. Despite their conspicuous location, the contribution of these myeloid ...
By subcluster analysis, MCs from the thyroid tissues and PBMCs of HT patients were divided into seven subgroups, named M1-M7, including two groups of monocytes (M1 and M3), two groups of macrophages (M4 and M7), and three groups of DCs (M2, M5, and M6) (Fig.8a, Supplementary Data...
12 The presence of renal interferon-γ (IFN-γ)–producing cells has not yet been assessed, although MPO-stimulated peripheral blood mononuclear cells from patients with AAV have been reported to produce IFN-γ.13 Moreover, monocytes/macrophages (the major Th1 effector leukocytes) are the ...
Here, multiple strategies were used to identify the protective source of TRAIL and its mechanism(s) of action. Samples from patients with coronary artery disease and bone-marrow transplantation experiments in mice lacking TRAIL revealed monocytes/macrophages as the main protective source. Accordingly, ...
The role of glia in amyotrophic lateral sclerosis (ALS) is undeniable. Their disease-related activity has been extensively studied in the spinal cord, but only partly in the brain. We present herein a comprehensive study of glia in the cortex of SOD1(G93