Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseases. Biomark Res. 2014; 2 (1):1. doi: 10.1186/2050-7771-2-1. [ Cross Ref ]Yang J., Zhang L., Yu C., Yang X., Wang H. Monocyte and macrophage differentiation: circulation ...
(angiogenesis/arteriogenesis), but also in any type oftissue damage, including host–pathogen interaction, cancer,atherosclerosis,cardiac diseasesand auto-immune diseases.Monocyteshave been recognized as cells with great plasticity, which may differentiate into DCs,macrophage subsets, and proangiogenic cells...
As CSF1R is normally reduced when monocytes differentiate into macrophages, this observation points towards a potential defect in monocyte maturation in the patient. Next, we investigated the consequences of decreased QKI expression on monocyte to macrophage differentiation. For this, we obtained freshly...
Chrobok NL, Sestito C, Wilhelmus MM, et al.Is monocyte- and macrophage-derived tissue transglutaminase involved in inflammatory processes-[J] Amino Acids, 2017, 49(3): 441-452.Chrobok, N.L.; Sestito, C.; Wilhelmus, M.M.; Drukarch, B.; van Dam, A.M. Is monocyte- and macrophage-...
Given that ANGPTL4 is highly expressed in macrophage-derived foam cells, we sought to determine the role of macrophage-specific ANGPTL4 during atherogenesis. To this end, Ldlr−/− mice were lethally irradiated and transplanted with the BM from Angptl4−/− and WT donor mice. Reconstitutio...
This differential recruitment based upon Ly6C expression may condition the macrophage phenotype within the plaque, with reports that Ly6C+ monocytes differentiate into cells that resemble M1 macrophages and that cells derived from Ly6C- monocytes exhibit M2 characteristics [62–65]. Chemokine receptors ...
In response to local factors, monocytes migrate into the inflamed site where they may differentiate into macrophages which exhibit either pro-inflam- matory or anti-inflammatory/pro-angiogenic functions. These divergent functions of macrophages are dependent mainly on the macrophage subs...
macrophage reservoirs when they exit the blood and differentiate into monocyte-derived macrophages (MDM). Thus, we have developed an MDM quantitative viral outgrowth assay (MDM-QVOA) for HIV. We have quantitated the replication-competent and DNA MDM reservoirs in a longitudinal cohort of vsPWH ...
As known, monocytes can differentiate either into macrophages or dendritic cells, depending upon the milieu. In case of infection, macrophages get differentiated into- Macrophages,for the purpose of eliminating the microbes by phagocytosis. Replenishing the resident macrophage population in the tissue is...
In absence of overt inflammation, monocytes also extravasate into selected tissues, where they complement tissue-resident macrophage compartments. Adjustment of these homeostatic monocyte infiltrates to local environment is critical to maintain health, as best established for the intestine. Defined gene ...