Genetic manipulation experiments demonstrated that overexpression of PPM1A attenuated the macrophage differentiation program, while knockdown of PPM1A expression accelerated the ability of monocytes to differentiate into macrophages. We identify imiquimod and Pam3CSK4 as two Toll-like receptor agonists that ...
Monocytes have been recognized as cells with great plasticity, which may differentiate into DCs, macrophage subsets, and proangiogenic cells, depending on the tissue environment, with different phenotypes and functions. Circulating monocytes are also heterogeneous, and can be subdivided, based on surface...
Viral encephalitis and multiple sclerosis are examples of important human diseases in which the pathogenic contribution of monocytes recruited from the bone marrow plays a critical role in the clinical expression of disease, as they differentiate into macrophage or dendritic cells in the CNS to carry ...
As CSF1R is normally reduced when monocytes differentiate into macrophages, this observation points towards a potential defect in monocyte maturation in the patient. Next, we investigated the consequences of decreased QKI expression on monocyte to macrophage differentiation. For this, we obtained freshly...
Monocyte/macrophage differentiation represents a major branch of hematopoiesis and is a central event in the immune response, but the molecular mechanisms underlying are not fully delineated. Here we show that p38 mitogen-activated protein kinase (MAPK)
Chrobok NL, Sestito C, Wilhelmus MM, et al.Is monocyte- and macrophage-derived tissue transglutaminase involved in inflammatory processes-[J] Amino Acids, 2017, 49(3): 441-452.Chrobok, N.L.; Sestito, C.; Wilhelmus, M.M.; Drukarch, B.; van Dam, A.M. Is monocyte- and macrophage-...
Peripheral blood CD14+ monocytes originate in the bone marrow and move via the bloodstream to infected or damaged peripheral tissue. Once at the tissue, monocytes differentiate into specific tissue macrophage or dendritic cells. These cells are responsible for phagocytosis of foreign substances in the ...
monocyte macrophage T cell inflammation innate immunity adaptive immunity effector T cell regulatory T cell Main Text A Brief Overview of Atherogenesis and Atherosclerotic Plaque Progression Atherogenesis is initiated by the entry and retention of apolipoprotein-B-containing lipoproteins (apoB LPs) into the...
Given that ANGPTL4 is highly expressed in macrophage-derived foam cells, we sought to determine the role of macrophage-specific ANGPTL4 during atherogenesis. To this end, Ldlr−/− mice were lethally irradiated and transplanted with the BM from Angptl4−/− and WT donor mice. Reconstitutio...
Chromatin undergoes extensive reprogramming during immune cell differentiation. Here we report the repression of controlled histone H3 amino terminus proteolytic cleavage (H3ΔN) during monocyte-to-macrophage development. This abundant histone mark in human peripheral blood monocytes is catalyzed by neutrophil...