Shoenfeld Y., Berliner S, Ayalone A, Shaklai M, Djaldetti M, Pick AI, Pinkhas J. Monoclonal gammopathy in patients with chronic and acute myeloid leukemia. Cancer 1984; 54, 280-283.Shoenfeld Y, Berliner S, Ayalone A, Shaklai M, Djaldetti M, Pick A, Pinkhas J (1984) ...
Monoclonal gammopathy of undetermined significance(MGUS) is defined as the presence of a monoclonal protein without features of multiplemyeloma(MM) or other related malignant plasma-cell disorder such asWaldenström macroglobulinemia,primary amyloidosis, B-cell lymphoma, orchronic lymphocytic leukemia.11,12...
Monoclonal gammopathy may result from multiple myeloma or solitary plasmocytoma, where the M-protein is mainly IgG or IgA, or from malignant lymphoproliferative diseases including Waldenström’s macroglobulinemia (WM), lymphoma, or chronic lymphocytic leukemia where the M-protein is IgM, as...
Mandatory major criteria • Chronic urticarial rash • Presence of monoclonal IgM or IgG gammopathy Minor criteria • Recurrent fever • Abnormal bone remodeling with or without pain • Neutrophilic dermatosis on skin biopsy • Leukocytosis and/or elevated C-reactive protein (CRP) Definite ...
The glomerular microangiopathy seen in POEMS syndrome is associated with a monoclonal gammopathy, which is nearly always λ light-chain type. However, the λ light chain itself is usually absent from kidney biopsy samples. Instead, the lesion is a subacute to chronic glomerular thrombotic micro...
In addition to the monoclonal gammopathy, bone abnormalities are often found at the site of bone pain in patients with SchS. The remarkable efficacy of interleukin-1 (IL-1) inhibition was also demonstrated in this syndrome. Case presentation: We describe a case of refractory chronic urticaria ...
A patient, with chronic myeloid leukemia and IgA monoclonal gammopathy, who contemporaneously developed myeloid blast crisis and immunoblastic lymphoma is reported. Cytogenetic studies showed complex chromosome abnormalities concerning chromosomes 8, 14 and 22, other than the Ph chromosome. A possible relat...
Oncogenic drivers of progression of monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma (MM) such as c-MYC have downstream effects on intracellular metabolic pathways of clonal plasma cells (PCs). Thus, extracellular environment
Monoclonal gammopathy of undetermined significance MIDD: Monoclonal immunoglobulin deposition disease MM: Multiple myeloma MPGN: Membranoproliferative glomerulonephritis NAS: Nonsense-associated altered splicing NHL: Non-Hodgkin lymphoma NSG: NOD/SCID gamma null ...
Monoclonal gammopathy 45 (100) IgM 45 (100) κ 19 (42) λ 21 (49) κ and λ 5 (11) Associated hematologic malignancies 17 (38) Waldenström macroglobulinemia 9 (20) Diffuse large B-cell lymphoma 2 (4) Monoclonal B lymphocytosis 2 (4) Marginal zone lymphoma 1 (2) Chronic lymphocytic...