Described herein is technology for determining the 2-D or 3-D atomic resolution structure of a polynucleotide bound to and/or interacting with another molecule, for example a small molecule. In some aspects of the technology, NMR and isotopic labeling strategies are used. The technology described...
The drug-like properties of a chemical compound are defined by its structure, such as molecular weight, hydrogen bonding,lipophilicity, pKa, polar surface area, shape and reactivity; by its physicochemical characteristics, such as solubility, permeability and chemical stability; andby its biochemical ...
- 《Nucleic Acids Research》 被引量: 21发表: 2015年 Correlated Movement and Bending of Nucleic Acid Structures Visualized by Multicolor Single-Molecule Spectroscopy At the end of the rainbow… The structure and dynamics of three- and four- way DNA junctions are studied using triple alternating ...
000 chemical structure–text pairs. To demonstrate the effectiveness and utility of MoleculeSTM, we design two challenging zero-shot tasks based on text instructions, including structure–text retrieval and molecule editing. MoleculeSTM has two main properties: open vocabulary and compositionality via ...
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However, significant issues surrounding the accuracy of SJs, TSS, and TES identification suggest that many of the above transcriptome studies would benefit from improved methods of transcript structure determination. Accurate and well-curated transcripts also play an important role in improving genome ...
Image: Molecular Structure of ATP Energy is released by hydrolysis of the third phosphate group. After this third phosphate group is released, the resulting ADP (adenosine diphosphate) can absorb energy and regain the group, thus regenerating an ATP molecule; this allows ATP to store energy like...
interaction causal reasoning and pathway enrichment with the transcriptional data derived from Anle138b-treated RCNs, and target prediction using its chemical structure, we were able to hypothesise several alternative mechanisms of action of Anle138b with evidence across all types of computational ...
J. et al. Direct observation of structure–function relationship in a nucleic acid-processing enzyme. Science 348, 352–354 (2015). Article ADS Google Scholar Desai, V. P. et al. Co-temporal force and fluorescence measurements reveal a ribosomal gear shift mechanism of translation regulation ...
Sequencing of nucleic acids with nanopores has emerged as a powerful tool offering rapid readout, high accuracy, low cost and portability. This label-free method for sequencing at the single-molecule level is an achievement on its own. However, nanopores