Topics in Nucleic Acid Structure : Topics in Molecular and Structural Biology; volume 1 edited by S. Neidle General editors: W. Fuller and S. Neidle MacMil... D Shugar - 《Febs Letters》 被引量: 0发表: 1982年 A standard reference frame for the description of nucleic acid base-pair ...
Structure representation is as in Fig. 2, except that sidechain carbons are in silver and mainchain carbons are in green. Vertical dashed lines mark the position of the β-MIDAS motif D8 Cα atom in αIIbβ3 state 1 (d). g Sequences of all human integrin βI domains in regions that ...
While this problem can be overcome with chemical modifications that are introduced post-selection9, care must be taken not to disrupt the activity of the catalytic domain. Artificial genetic polymers, commonly referred to as xeno-nucleic acids (XNAs), provide an alternative solution to the problem...
Structure and mechanism in complex general acid-base catalyzed reactions The mechanisms of acid and base catalyzed carbonyl and acyl group reactions are determined largely by the lifetime of the initial addition intermeidate. Catalysis through diffusion-controlled trapping by relatively strong acids or ...
Chemistry and X-ray crystallographic structure of N-protected(5-oxo-1,3-oxazolidin-4-yl)acetic acids: versatile intermediates in thesynthesis of peptidomim... The X-ray crystal structures of [(2′R,4′S)-3′-benzoyl-4′- benzyl-5′-oxo-2′-phenyloxazolidin-4′-yl]acetic acid 16 and ...
Several classes of drug have since been discovered which depend for their effect on some kind of modification of the proper functioning of nucleic acids. Intercalators and alkylating agents were among the earliest therapeutic agents which were recognized as behaving in this way and were widely used ...
The criteria used during the past three decades for including viruses in the potyvirus group are briefly discussed and evaluated. The biological and physico-chemical properties of the viruses transmitted by aphids, mites, whiteflies, or the fungus Polymy
The ModelSEED Biochemistry Database for the integration of metabolic annotations and the reconstruction, comparison and analysis of metabolic models for plants, fungi and microbes. Nucleic Acids Res. 2021;49(D1):D575-d588. Article CAS PubMed Google Scholar Barrett T, Wilhite SE, Ledoux P, ...
Structure of CedA bound to the open-promoter complex To gain further insight into the mechanism of CedA, we used cryo-EM to solve the structure of CedA bound to the RNAPσ70-open-promoter complex. Purified RNAPσ70 holoenzyme was first incubated with 85-bp DNA representing −60 to +25...
(c) Chemical structure of the acid-cleavable and isotope-coded biotin-azide used for chemoproteomics experiments. (d) Structure of the peptide-compound conjugates to be detected from the mass spectrometry. Note the 3:1 ratio of the isotope tag that allows reliable identification of the conjugates...