These metabolic and redox changes are orchestrated and regulated by the cooperative and/or antagonistic actions of nuclear factor (NF-κB), HIF1α, the mechanistic target of rapamycin (mTOR), and the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway. Mitogen-activated ...
It was found that E80 administration promoted overload-induced hypertrophy and induced phosphorylation of the Akt/mammalian target of rapamycin (mTOR) pathway proteins, such as Akt, P70 ribosomal protein S6 kinase (p70S6K), and S6 in the plantaris muscle. Therefore, functional overload and E80 ...
Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and anabolism to generate cellular energy and structural components. The emerging field of immunometabolism highlights the importance of cellular metabolism for the maintenance and activities of immune cells. Macrophages are embr...
Ferroptosis, a relatively new form of cell death first discovered in 2012, is induced by small molecule compound erastin (an inducer of ferroptosis) and dependent on iron and lipid peroxidation, which is different from autophagy, pyrosis and other forms of cell death [1]. The morphological feat...
In this study, the performance of the novel biodegradable PHBHHx-PEG copolyester as a sustained release carrier for hydrophobic drugs with different molecular weights and the in vitro sustained release profile were investigated. 5-Fluorouracil(5-Fu, Mw=130.1), TGX221(Mw=364.4), and Rapamycin(RAP...
Gangliosides inhibited IL-2-stimulated proliferation in synchronized populations of the IL-2-dependent cell lines CTLL-2 and HT-2. The immunosuppressive ... J.W.K. Chu,FJ Sharom - 《Immunology》 被引量: 67发表: 1993年 The effect of the immunophilin ligands rapamycin and FK506 on proliferati...
Mammalian target of rapamycin References Schilter B, Andersson C, Anton R, Constable A, Kleiner J, O’Brien J et al (2003) Guidance for the safety assessment of botanicals and botanical preparations for use in food and food supplements. Food Chem Toxicol 41(12):1625–1649 Article CAS Pub...
Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation. J Pineal Res. 2018;64:e12461. Article Google Scholar Zhang HM, Zhang Y. Melatonin: a well-...
Finally, our results also demonstrate that Aβ oligomer treated neurons exhibit elevated levels of activated Akt and mTOR (mammalian Target Of Rapamycin) and that PI3K, Akt or mTOR inhibitors blocked Aβ oligomer-induced neuronal CCEs. Taken together, these results demonstrate that Aβ oligomer-...
An ID of rapamycin was also given for three different periods (time model): 1, 4 and 8 weeks; four mice were in each group. Mice treated with dimethyl sulphoxide served as controls. Body weight was measured weekly. Renal function was assessed by serum creatinine at the time of sacrifice....