Initial attempts to unravel the molecular mechanism of insulin resistance have strongly suggested that a defect responsible for insulin resistance in the majority of patients lies at the post-receptor level of insulin signaling. Subsequent studies in insulin-resistant animal models and humans have ...
(2005) Molecular mechanisms of insulin resistance. Diabet Med 22: pp. 674-682 CrossRef White, M.F. (2002) IRS proteins and the common path to diabetes. Am J Physioi Endocrinol Metab 283: pp. E413-E422 Ahima, R.S. (2006) Adipose tissue as an endocrine organ. Obesity (Silver Spri...
Insulin resistance is the defining feature of the metabolic syndrome and the primary defect leading to type 2 diabetes. Insulin resistance is a pathologica... G Hsiao - University of California, San Diego. 被引量: 0发表: 2010年 Molecular mechanisms of insulin resistance in diabetes. Molecular co...
However, it is probable that the majority of the molecular defects causing insulin resistance occur at the postreceptor level. The key proteins involved in the different intracellular signalling pathways of insulin are only partly identified. A better understanding of the mechanisms of insulin action ...
Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance.Author(s): K Ueki, A Virkamäki, Valerie C Kahn Publication date: 1999-03-31 Journal: The Journal of clinical investigation Keywords: Animals, Gene Targeting, Humans, Insulin, metabolism, Insulin ...
Molecular mechanisms of insulin resistance in type 2 diabetes mellitus World J. Diabetes, 1 (July (3)) (2010), p. 68 CrossrefGoogle Scholar [70] M. Tiedge, S. Lortz, J. Drinkgern, S. Lenzen Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-pr...
Objective To investigate the reversal effect and molecular mechanisms of NF-κB inhibitor parthenolide( PTL) on insulin resistance( IR). Methods Hep G2 cells were treated with insulin at different concentrations and time points,the glucose consumption of Hep G2 cells was measured via glucose oxidase...
G. Molecular mechanisms of insulin resistance in polycystic ovary syndrome. Trends Mol Med 12, 324–332, doi: 10.1016/j.molmed.2006.05.006 (2006). Article CAS PubMed Google Scholar Wu, S., Divall, S., Wondisford, F. & Wolfe, A. Reproductive tissues maintain insulin sensitivity in ...
In addition to direct effects of insulin on signalling kinases and metabolic enzymes, the discovery of mechanisms of insulin-regulated gene transcription has led to a reassessment of the general principles of insulin action. These advances will accelerate the discovery of new treatment modalities for ...
Although the exact underlying mechanisms are still unknown, obesity is recognized as a risk factor for AD and the condition of insulin resistance seems to be the link between the two pathologies. Using mice with high fat diet (HFD) obesity we dissected the molecular mechanisms shared by the ...