Insulin resistance, the impaired action of insulin, has been linked to many important consequences, including Type 2 diabetes, hypertension, dyslipidemia, acanthosis nigricans and polycystic ovarian syndrome. Although there are some genetic causes for insulin resistance, the most common cause is an ...
Accumulation of ectopic lipid metabolites, activation of the unfolded protein response (UPR) pathway, and innate immune pathways have all been implicated in the pathogenesis of insulin resistance. However, these pathways are also closely linked to changes in fatty acid uptake, lipogenesis, and energy...
Mechanisms of insulin resistancedoi:10.1038/s41574-018-0083-4Greenhill ClaireNature Reviews Endocrinology
Obesity increases the risk for type 2 diabetes through induction of insulin resistance. Treatment of type 2 diabetes has been limited by little translation
Proposed mechanisms for the induction of insulin resistance by oxidative stress. Antioxid. Redox Signal. 2005; 7 :1553–1567. doi: 10.1089/ars.2005.7.1553. [ Cross Ref ]Bloch-Damti A, Bashan N. Proposed Mechanisms for the Induction of Insulin Resistance by Oxidative Stress. Anti...
Insulin signaling; Receptor regulation; Basis for the multiple and tissue-specific actions of insulin; Syndromes of insulin resistance; Conclusions.MollerD.E.FlierJ.S.New England Journal of MedicineMoller DE, Flier JS. Insulin resistance--mechanisms, syndromes, and implications. N Engl J Med 1991;...
用空腹C肽代替胰岛素改良Homa公式评价胰岛素抵抗和胰岛β细胞功能 Replacement of insulin by fasting C-peptide in modified homeostasis model assessment to evaluate insulin resistance and islet β cell function 热度: Mechanisms linking obesity to insulin resistance and type 2 diabetes ...
Insulin Resistance Due to Phosphorylation of Insulin Receptor Substrate-1 at Serine 302 Inhibitory serine phosphorylation is a potential molecular mechanism for insulin resistance. We have developed a new variant of the yeast two-hybrid method... Eric,D.,Werner,... - 《Journal of Biological Chemist...
Obesity is associated with an increased risk of developing insulin resistance and type 2 diabetes. In obese individuals, adipose tissue releases increased amounts of non-esterified fatty acids, glycerol, hormones, pro-inflammatory cytokines and other factors that are involved in the development of insu...
Compared to data from a large group of normal subjects, the resistance to insulin during infection corresponded to that predicted for a weight-matched 84-yr-old normal person or an age-matched obese person with a body mass index of 37 kg/m2. One to 3 months after recovery, the patients'...