ABOUBAKAR, M.; PUISIEUX, F.; COUVREUR, P.; DEYME, M.; VAUTHIER, C. Study of the mechanism of insulin encapsulation in poly(isobutylcyanoacrylate) nanocapsules obtained by interfacial polymerization. J. Biomed. Mater Res., New York, v. 47, p. 568-576, 1999....
The Molecular Mechanism of Insulin Action Insulin initiates its action by binding to a glycoprotein receptor on the surface of the cell. This receptor consists of an alpha-subunit, which binds the ... Kahn,C R - 《Annual Review of Medicine》...
We explored the possible mechanism of statin induced insulin resistance using a well-established cell based model and simvastatin as a prototype statin. Our data show that simvastatin induces insulin resistance in a cholesterol biosynthesis inhibition independent fashion but does so by a fatty acid ...
Compared to healthy controls, T2DM patients exhibit a greater percentage of Enterobacteriaceae, Collinsella, Streptococcus, Lactobacillus and Lachnospiraceae/Ruminococcus, which was important in activating lower levels of inflammation and exacerbating insulin resistance (Candela et al.2016). In addition, the...
In vitro, GLA has an insulin receptor (IR) profile similar to human insulin (HI) but slightly higher affinity for the IGF-1 receptor (IGF1R). InU WernerR SchmidtE BlairDiabetesWe...
Insulin3 has a similar structure to pro-insulin and mature IGF ligands, but cannot activate the IGF1 receptor. However, similar to IGFs, Insulin3 induced the gene expression of an anterior neural marker, otx2 and enlarged anterior head structures by inhibiting Wnt signalling. Insulin3 are ...
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Atienzar FA, Blomme EA, Chen M et al (2016) Key challenges and opportunities associated with the use of in vitro models to detect human DILI: integrated risk assessment and mitigation plans. Biomed Res Int 2016:9737920. https://doi.org/10.1155/2016/9737920 Article CAS PubMed PubMed Centra...
Yang Xin Tang (YXT) is a traditional Chinese herbal preparation which has been reported to improve cognitive function and memory in patients with dementia. As the underlying mechanism of action of YXT has not been elucidated, we examined the effects of Y
Zhou XX, Chen N, Xu HZ, et al. Regulation of Hippo-YAP signaling by insulin-like growth factor-1 receptor in the tumorigenesis of diffuse large B-cell lymphoma[J/OL]. J Hematol Oncol, 2020, 13(1): 77[2022-04-01].https://jhoonline.biomedcentral.com/articles/10.1186/s13045-020-00906...