Insulin resistance is commonly associated with obesity, although not all individuals with obesity have insulin resistance, and insulin resistance may be present in persons without obesity. Insulin resistance can have important adverse consequences on the vasculature and blood pressure, thought to be ...
Obesity increases the risk for type 2 diabetes through induction of insulin resistance. Treatment of type 2 diabetes has been limited by little translation
Obesity is associated with an increased risk of developing insulin resistance and type 2 diabetes. In obese individuals, adipose tissue releases increased amounts of non-esterified fatty acids, glycerol, hormones, pro-inflammatory cytokines and other factors that are involved in the development of insu...
obesityinsulin resistancecytokinesinflammationmacrophagesinsulin signalingChronic systemic low-grade inflammation is a hallmark of obesity and insulin resistance associated with aging. Mechanisms that underlie inflammation and link it to insulin resistance in obesity are of crucial importance for understanding age...
Molecular Mechanism of Insulin Resistance and Obesity Obesity and insulin resistance have been recognized as leading causes of major health issues. We have endeavored to depict the molecular mechanism of insul... T Kadowaki,K Hara,T Yamauchi,... - 《Experimental Biology & Medicine》 被引量: 453...
N. Abate, "Insulin resistance and obesity: the role of fat distribution pattern," Diabetes Care, vol. 19, no. 3, pp. 292- 294, 1996... N Abate - 《Diabetes Care》 被引量: 215发表: 1996年 Insulin resistance and obesity. The role of fat distribution pattern. N. Abate, "Insulin res...
Contribution of glucose oxidation and glucose storage into glycogen to insulin resistance; Association of weight reduction and insulin resistance; Issues related to the insulin resistance to the obese.FerranniniEleInternational Journal of Obesity
1. Introduction 2. Definition of obesity 3. Prevalence and incidence of obesity 4. Risk factors of obesity 5. Cellular dysfunctions associated with obesity-induced insulin resistance 6. Conclusion Funding Declaration of Competing Interest ReferencesShow full outline Cited by (406) Figures (5)Biomedic...
Insulin resistance is a hallmark of obesity and a forerunner of type 2 diabetes mellitus (T2DM). Obesity-induced lipotoxicity and inflammation impair insulin sensitivity through activation of intracellular protein kinases. Sexual dimorphism in insulin re
Following unregulated production of such molecules, adipose tissue dysfunction results, contributing to complications associated with obesity. Previous studies have implicated pro- and anti-inflammatory substances in the regulation of inflammatory response and in the development of insulin resistance. In obese...