This article will discuss the chemical nature of drug affinity and efficacy, as well as the application of these concepts to drug agonism (whereby a molecule actively produces a physiological response), drug antagonism (where the drug prevents the action of an endogenous molecule that produces an ...
pharmacodynamicsregimenstuberculosisThis review of short-course chemotherapy of pulmonary tuberculosis covers the mechanisms of drug action, drug toxicity, regimens... W Fox - 《British Journal of Diseases of the Chest》 被引量: 262发表: 1981年 Increased CDA expression/activity in males contributes to...
Because of its high expression in the intestine, the DDIs mediated by P-gp often occur during the drug absorption phase [6]. Therefore, elucidating the mechanism of DDIs mediated by transporters and reducing the unknown factors that affect the effectiveness and safety of drugs are of extremely...
In this review, we focus on the mechanism of action of raltegravir in vitro and in vivo and we present the structural data that shed light on the molecular basis of its inhibitory potency and on the origin of the emergence of resistance. 1. Integrase Biochemistry Catalytic activity Virological...
ONE of the chief difficulties in the interpretation of the analogies between the biological activity of a drug and its behaviour in synthetic systems arises from the ambiguity of toxicological data, which may generally be correlated with solubility in th
Drug-induced gingival overgrowth (DIGO) is one of the side effects produced by therapeutic agents, most commonly phenytoin, nifedipine and cyclosporin A. However, the precise mechanism of DIGO is not entirely understood. A literature search of the MEDLINE/PubMed databases was conducted to identify ...
Chemistry and Molecular Aspects of Drug Design and Action49 3/1 返回列表 查看: 2208 | 回复: 48 只看楼主@他人 存档 新回复提醒 (忽略) 收藏 在APP中查看 相关版块跳转 药学 我要订阅楼主 york6999 的主题更新 49 3/1 返回列表 ☆ 无星级 ★ 一星级 ★★★ 三星级 ★★★ 五星级 普通表情 ...
It is a new cross-discipline based on the theory of systems biology to study the mechanism of drug action and design multi-target drug molecules at the system level. TCM network pharmacology is a new research paradigm, which aims to transform traditional Chinese medicine from experience-based ...
Yinchen Wuling powder is often used to treat clinical hyperlipidemia, although its mechanism of action remains unclear. In this study, we aimed to investigate the active ingredients found in Yinchen Wuling powder and find its mechanism of action when treating hyperlipidemia, using a combination of ...
Network pharmacology is a new method of drug research proposed based on multi-directional systematic pharmacology and biology [23,24,25], which combines drug component target network with biological target network from multiple perspectives to study the mechanism of drug action more systematically and ...