We used protein–protein and compound–compound correlation networks to uncover mechanisms of action for several compounds, including the adrenergic receptor antagonist JP1302, which we show disrupts the FACT complex and degrades histone H1. By profiling many compounds with overlapping targets covering ...
Mechanisms of Drug Action 药物作用机制 药物是一种可以影响人体生理和行为的化学物质。药物的作用主要在于改变生命体内的化学过程和反应。药物作用机制是指药物分子与生命体内分子相互作用的过程。了解药物作用机制是药物研究的基础,也是开发新药物的关键。 药物作用的基础机制:分子与生物体内分子相互作用 药物是在生物...
1. 药物反应机理 计划中包括一 门必修课,如:基本原理或药理学和治疗学或药物反应机理(mechanisms of drug action)。第三学期进行博士 …lantianyu.net|基于1 个网页 例句 释义: 全部,药物反应机理 更多例句筛选 1. Mechanisms of drug action and resistance in Mycobacterium tuberculosis 抗结核药物的作用机制及结...
Mechanisms of Drug Action on the Nervous System 作者:Ryall, R.W. 出版年:1989-5 页数:256 定价:$ 61.02 ISBN:9780521274371 豆瓣评分 目前无人评价 在哪儿借这本书· ··· 上海图书馆(1)
carcinogens can be classified as being genotoxic, nongenotoxic, or both dependent upon their mechanism(s) of action. Drugs that interact directly with DNA to cause damage to it are considered to be genotoxic, while drugs that cause cancer through indirect mechanisms are considered to be nongenotox...
Mechanisms of Drug Action and Resistance (Focus on Antimalarials)Action, DrugToxicity, Selective
In this book the targets of drug action are the central focus - whether they be enzymes in a pathway or membrane-bound receptors and ion channels. This approach distinguishes the book from others in the f ield which consider the subject mainly in terms of disease. The introductory chapter is...
Prospective pan-cancer IDACombo predictions reveal patterns based on drug mechanisms of action Given the encouraging validation results in both in vitro and clinical trial data, we chose to create efficacy predictions for all possible two-drug combinations of clinically advanced drugs available in CTRP...
The structure-activity relationship describes the connection between chemical structure and biological effect. Such a relationship explains theefficaciesof various drugs and has led to the development of newer drugs with specific mechanisms of action. The contribution of the British pharmacologist SirJames ...
This chapter reviews the modes of action and mechanisms of P. falciparum resistance to the antifolate drugs sulfadoxine-pyrimethamine, pyrimethamine, and cycloguanil, as well as the quinoline-based drugs, notably chloroquine, mefloquine, and quinine. Discussion of the resistance mechanisms focuses on...