Whereas the former changes are slower in onset but longer in duration, the latter are more rapid and transient. Steroid types of receptors, ion channels, and G-protein-coupled receptors are among the prototypical ones discussed in this article. Further, the interactions of drugs with enzymes, ...
n.1.(Medicine, Biochemistry)The mechanism{2} by which a pharmacologically active substance produces an effect on a living organism or in a biochemical system; as, themechanism of actionof actinomycin involves its binding to DNA. The mechanism of action is usually considered to include an identifi...
Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR PXR is a receptor activated by diverse compounds that triggers detoxification pathways in the cell, and blocking this receptor may increase the effectiveness of certain drugs. Here, the authors present the structural...
Tang, Zhang, Fang, Zhu et al. identify impaired mitochondrial fusion and biogenesis as a key mechanism underlying NOTCH1-associated aortic pathology and show that correcting mitochondrial loss in mutant mice using repurposed drugs teriflunomide or leflunomide slows the progression of aoropathy. ...
Despite the bewildering number of diuretics available to the physician, these drugs can be divided into 4 main groups, characterised by their site of action on sodium reabsorption in the kidney. Drugs acting on the ascending limb of the loop of Henle have a powerful but short acting diuretic ...
(s) of Action Blocks dopamine 2 receptors, dopamine D2, his- tamine H1, and cholinergic M1 blockade in the vomiting center (area postrema) Indication Schizophrenia, nausea, vomiting, restlessness before surgery, manic episodes of bipolar disor- der, and tetanus Physicians' desk reference (6...
Possible anti-inflammatory role of COX-2 In 1971, Sir John Vane demonstrated for the first time that the mechanism of action of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs)... M Kapoor,O Shaw,I Appleton - 《Current Opinion in Investigational Drugs》 被引量: 52发表: 200...
a这是我和我的小姨 This is I and my sister-in-law [translate] aMechanism of action, indications and abuse of benzodiazepine anxiolytic drugs]. 行动, benzodiazepine anxiolytic 药的迹象和弊病的机制 )。 [translate] 英语翻译 日语翻译 韩语翻译 德语翻译 法语翻译 俄语翻译 阿拉伯语翻译 西班牙语翻译 ...
Denosumab has a novel mechanism of action; it binds to receptor activator of nuclear factor 魏B ligand and inhibits bone resorption by inhibiting osteoclast... MD Moen,SJ Keam - 《Drugs & Aging》 被引量: 32发表: 2011年 Targeted approaches in the treatment of osteoporosis: differential mechanism...
Furthermore, the high cost of oncology drugs may limit their clinical application in certain countries [10]. Thus, many cancer patients, not just limited to advanced stage patients, seek complementary and alternative medicine (CAM) treatments in an attempt to improve therapeutic efficacy and/or ...