AIMS. To compare the effects of moderate-intensity statin plus ezetimibe combination therapy to high-intensity statin monotherapy based on baseline low-density lipoprotein cholesterol (LDL-C) levels. METHODS AND RESULTS. In the RACING trial, 3780 atherosclerotic cardiovascular disease (ASCVD) patients ...
The risk of MACCE was lower in the moderate-intensity statin plus ezetimibe group compared to the high-intensity statin group among patients who underwent PCI due to angina (HR, 0.89; 95% CI, 0.80–0.98). The impact of high-intensity statin therapy on the risk of new-onset DM was ...
It would have been much more valuable if the authors compared the efficacies among low, moderate, and high intensity statins in this diabetes cohort. Nevertheless, it is still of great clinical significance because it provides a rationale that early, modest statin treatment can normalize LDL-C in...
Statin therapy in patients with mild to moderate coronary stenosis by 64-slice multidetector coronary computed tomographyPark, H ECho, G YChoi, S IChun, E JKim, H KKim, Y JChoi, D JSohn, D W
3-5 Many patients receiving moderate- or high-intensity statin therapy are unable to achieve these recommended goals with statin therapy, and consideration of nonstatin therapy for additional LDL-C lowering has been recommended.4-8 Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors ...
A moderate intensity endurance and resistance exercise training program improves muscle performance, capillarization, and mitochondrial content in both asymptomatic and symptomatic statin users without exacerbating muscle complaints. Exercise training may even increase quality of life in symptomatic statin users...
cmd=Retrieve&db=PubMed&list_uids=8484829&dopt=AbstractGoogle Scholar High-Intensity Statin Treatment for Coronary Heart Disease JAMA Editorial March 3, 2004 See More About Cardiology Dyslipidemia Cardiovascular Risk Factors Trending Lesion-Level Effects of LDL-C–Lowering Therapy in Patients With Acute...
Qualifying patients who provided written, informed consent were randomized in a 1:1 ratio to receive apabetalone 100 mg orally twice daily or matching placebo, in addition to high-intensity statin therapy with atorvastatin or rosuvastatin and other clinically defined standard of care. The primary ...
Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis.The article discusses a study which confirmed findings on the increased risk of developing new-onset diabetes through intensive-dose statin therapy when compared to moderate-dose statin therapy ...
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