[19].KimBK,etal.RACINGinvestigators.Long-termefficacyandsafetyofmoderate-intensitystatinwithezetimibecombinationtherapyversushigh-intensitystatinmonotherapyinpatientswithatheroscleroticcardiovasculardisease(RACING):arandomised,open-label,non-inferioritytrial.Lancet.2022Jul30;400(10349):380-390. [20].ChristopherPCannon...
(4) Conclusions: In high-complex RA PCI, moderate/low-intensity statin therapy is not inferior to high-intensity statin therapy in Korea.Choi, Sang-SukJung, JinHer, Sung-HoKim, KyunyeonKim, YoungminLee, KyusupYoo, Ki-DongMoon, Keon-Woong...
Overwhelming evidence suggests that the benefits of statin therapy far outweigh any real or perceived risks. Key points Moderate-intensity and high-intensity statin therapy has demonstrated benefits in reducing the risk of atherosclerotic cardiovascular disease in both primary and secondary prevention. The...
Some studies have reported that, in patients with stable CAD, compared to low-dose or moderate-intensity statin therapy, high-dose or high intensity statin use can further improve CV outcomes10,11,12. However, in patients with CAD undergoing coronary intervention, the use of statins before ...
3-5 Many patients receiving moderate- or high-intensity statin therapy are unable to achieve these recommended goals with statin therapy, and consideration of nonstatin therapy for additional LDL-C lowering has been recommended.4-8 Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors ...
Accordingly, we designed the ASTEROID trial (A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden) to examine the effects of high-intensity statin therapy on IVUS-derived measures of coronary disease progression. Rosuvastatin is the most recently ...
moderate-intensity (95% CI 0·03–0·05) and high-intensity statin therapy (0·02–0·06), and the corresponding increases in HbA1c values were 0·06% (0·00–0·12) for low-intensity or moderate-intensity and 0·08% (0·07–0·09) for high-intensity statin therapy (appendix p ...
This study determined whether moderate intensity exercise training improved muscle and exercise performance, muscle mitochondrial function, and fiber capillarization in symptomatic and asymptomatic statin users. Methods Symptomatic (n = 16; age 64 ± 4 years) and asymptomatic statin users (n = 16; age...
Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial. JAMA. 2006;295(13):1556-1565.ArticlePubMedGoogle ScholarCrossref 6. Nissen SE, Tuzcu EM, Schoenhagen P, et al; REVERSAL Investigators. Effect of intensive compared with moderate lipid-...
Moderate-intensity statin therapy reduced baseline LDL-C levels by 29%, and high-intensity statin therapy reduced baseline LDL-C levels by 43%.23 Each 1.0-mmol/L (38.67-mg/dL) reduction in LDL-C level corresponded to a 0.76 relative risk for primary coronary heart disease and 0.85 relative...