We aimed to evaluate sex differences in the effects of moderate-intensity statin with ezetimibe combination therapy (rosuvastatin 10 mg plus ezetimibe) versus high-intensity statin (rosuvastatin 20 mg) monother
Some studies have reported that, in patients with stable CAD, compared to low-dose or moderate-intensity statin therapy, high-dose or high intensity statin use can further improve CV outcomes10,11,12. However, in patients with CAD undergoing coronary intervention, the use of statins before ...
Long-term efficacy and safety of moderate-intensity statin with ezetimibe combination therapy versus high-intensity statin monotherapy in patients with atherosclerotic cardiovascular disease (RACING): a randomised, open-label, non-inferiority trial
Importance In phase 2 studies, evolocumab, a fully human monoclonal antibody to PCSK9, reduced LDL-C levels in patients receiving statin therapy. Objective To evaluate the efficacy and tolerability of evolocumab when used in combination with a moderate- vs high-intensity statin. Design, Setting, ...
Over 50% reduction in LDL-C can be achieved, even when a high dose statin is not tolerated, by adding either ezetimibe or other non-statin pharmacotherapies in combination with low to moderate-intensity statin treatment (Figure 5). The results of the RACING study demonstrated that compared ...
Remarkably, after a short duration of statin therapy, the prevalence of TCFA was reduced from 20.0% to 7.1% (p = 0.003). Download: Download high-res image (700KB) Download: Download full-size image Central Illustration. High-Intensity Statins and Intracoronary Imaging, Cholesterol Efflux, and ...
Accordingly, we designed the ASTEROID trial (A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden) to examine the effects of high-intensity statin therapy on IVUS-derived measures of coronary disease progression. Rosuvastatin is the most recently ...
Statin therapy in patients with mild to moderate coronary stenosis by 64-slice multidetector coronary computed tomographyPark, H ECho, G YChoi, S IChun, E JKim, H KKim, Y JChoi, D JSohn, D W
high-intensity statin is not tolerated, or a response to therapy is judged not adequate — that was the language — the data support using a moderate-intensity statin, to which a non-statin such as ezetimibe can be added....
Across-study comparisons did not indicate differences in outcomes based on dose titration vs fixed-dose statin therapy or based on statin intensity. As noted, most trials used a moderate-intensity statin.13,31Harms of Preventive Medication