The upfront use of a moderate-intensity statin plus ezetimibe may improve LDL-C control and lead to the prevention of CVD in real-world settings.doi:10.1007/s40265-024-02113-5Li, ShaLiu, Hui-HuiLi, Jian-JunSpringer International PublishingDrugs
Long-term efficacy and safety of moderate-intensity statin with ezetimibe combination therapy versus high-intensity statin monotherapy in patients with atherosclerotic cardiovascular disease (RACING): a randomised, open-label, non-inferiority trial
y: a meta-analysis. Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis.Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis.The article discusses a study which confirmed findings on the ...
Efficacy and Safety of Fenofibric Acid Co-Administered with Low- or Moderate-Dose Statin in Patients with Mixed Dyslipidemia and Type 2 Diabetes Mellitus[J] . Peter Jones,Kenneth Cusi,Michael Davidson,Maureen Kelly,Carolyn Setze,Kamlesh Thakker,Darryl Sleep,C. Stolzenbach.American Journal of ...
Levels of HDL-C were modestly increased by 5% to 10% across both the every-2-weeks and the monthly dose groups (4%-10% vs placebo at the mean of weeks 10 and 12) (eTables 3 and 6 and eFigure 2 in Supplement). Baseline PSCK9 levels were higher in the high-intensity statin ...
Signal-to-noise ratio (mean signal intensity/standard deviation of signal intensity) of the CTDE scan was estimated using a 10-mm2 region of interest in the left ventricle. MDCT Radiation Exposure Estimation Effective radiation dose exposure for each component of the MDCT comprehensive protocol (...
Qualifying patients who provided written, informed consent were randomized in a 1:1 ratio to receive apabetalone 100 mg orally twice daily or matching placebo, in addition to high-intensity statin therapy with atorvastatin or rosuvastatin and other clinically defined standard of care. The primary ...
Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis. JAMA. 2011;305:2556–64. Corroboration of the increased diabetes risk with statin therapy, showing that high-intensity statin therapy led to the greatest risk of diabetes .Preiss D, Seshas...
The rate of discontinuation or dose reduction of study drugs due to intolerance was lower in the ezetimibe combination group than in the high-intensity statin monotherapy group in both women (4.5% vs. 8.6%, P = 0.014) and men (4.8% vs. 8.0%, P < 0.001). LDL cholesterol levels of < ...
The article discusses a review of randomized controlled trials (RCTs) which investigated the effect of intensive-dose statin therapy on the risk for incident diabetes mellitus (DM). Outcomes analyzed include the development of incident DM, and a composite of cardiovascular (CV) events, such as ...