Mode of action: Developmental thyroid hormone insufficiency-neurological abnormalities resulting from exposure to propylthiouracil. Crit. Rev. Toxicol. 35, 771-781.Zoeller RT , Crofton KM . 2005 . Mode of action: developmental thyroid hormone insufficiency – neurological abnormalities resulting from ...
1The iodine-containing contrast medium iopanoic acid induces alterations of thyroid hormone metabolism comparable to those observed with the iodine-containing antiarrhythmic drug amiodarone. Both compounds inhibit the intracellular conve... M St?Ubli,H Studer - 《British Journal of Pharmacology》 被引...
2) It is specific; the presence of other hormones - insulin ACTH luteinizing hormone thyroid stimulating hormone follicle stimulating hormone or subprimate growth hormone - does not affect the binding. 3) It is high affinity binding (Ka=.15 X 10 M )meaning that most of the dose response ...
Knowledge on mode-of-action (MOA) is required to understand toxicological effects of compounds, notably in the context of risk assessment of mixtures. Such information is generally scarce, and often complicated by the existence of multiple MOAs per compound. Here, MOAs related to developmental crani...
In the apo- or antagonist-bound receptor, the AF-2 helix is destabilized from its “active” conformation to allow the LBD to interact with corepressors such as nuclear corepressor (N-CoR) and silencing mediator for retinoid and thyroid hormone receptors (SMRT; Chen and Evans 1995, Horlein ...
fatigue, lowering of IQ; — violation in the activity of the hormone of the pineal gland that lowers the anti-cancer protection, sleep disturbance; — lock the pineal gland and its calcification.It is important to remember that boiling the water only increases its content of fluorin...
Overall the aquatic toxicity data suggest that BDE-209 can have adverse effects on critical endpoints such as survival, growth, fitness, reproduction, development, somatic maintenance, thyroid hormone homeostasis and neurological function. 总体来说,水生毒性数据表明,BDE-209可以对关键的端点,例如生存、成...
The term molecular imprinting refers to Fischer's 'lock and key concept' [40], which explains the specific action of an enzyme with a single substrate, where the lock is the enzyme and key is the substrate. This theory helps to illustrate the specificity of enzymes towards a certain ...
Crofton KM, Zoeller RT: Mode of action: neurotoxicity induced by thyroid hormone disruption during development--hear- ing loss resulting from exposure to PHAHs. Crit Rev Toxicol 2005, 35:757-769.Crofton, K. M., and Zoeller, R. T. (2005). Mode of action: neurotoxicity induced by thyroid...
Mode of action: Developmental thyroid hormone insufficiency-neurological abnormalities resulting from exposure to propylthiouracil. Crit. Rev. Toxicol. 35, 771-781.Zoeller RT, Crofton KM. Mode of action: developmental thyroid hormone insufficiency: neurological abnormalities resulting from exposure to ...