Full-length NS3 and an N-terminal fragment of the protein bound the mitochondrial membrane lipid cardiolipin, permeabilized the mitochondrial membrane and induced mitochondrial dysfunction. Both the N-terminal region and the mitochondrial localization motif of NS3 were essential for cell death, viral ...
The mixed lineage kinase domain-like protein MLKL is a functional RIP3 substrate that binds to RIP3 through its kinase-like domain but lacks kinase activity of its own. RIP3 phosphorylates MLKL at the T357 and S358 sites. Reported here is the development of a monoclonal antibody that ...
Mlkl, CT (Mlkl, Mixed lineage kinase domain-like protein) (APC) 中文名: 中文别名: CBNumber: CB04965978 分子式: 分子量: 0 MOL File: Mol file 化学性质安全信息用途供应商1 Mlkl, CT (Mlkl, Mixed lineage kinase domain-like protein) (APC)化学性质 ...
英文名称:Mlkl, CT (Mlkl, Mixed lineage kinase domain-like protein) (APC) 英文同义词:Mlkl, CT (Mlkl, Mixed lineage kinase domain-like protein) (APC) CAS号: 分子式: 分子量:0 EINECS号: Mol文件:Mol File Mlkl, CT (Mlkl, Mixed lineage kinase domain-like protein) (APC) 信息错误报告 ...
Full-length NS3 and an N-terminal fragment of the protein bound the mitochondrial membrane lipid cardiolipin, permeabilized the mitochondrial membrane and induced mitochondrial dysfunction. Both the N-terminal region and the mitochondrial localization motif of NS3 were essential for cell death, viral ...
The mixed lineage kinase domain-like protein (MLKL) was first discovered in 2012 as the executioner of necroptosis. In line with this, we showed that MLKL knockdown (Mlkl KD) by administration of antisense oligonucleotides to atherosclerotic-prone Apoe-knockout (Apoe-/-) mice did indeed decrease...
During atherosclerosis, macrophages within the aorta undergo necroptosis, a mode of pro-inflammatory cell death that is triggered by the phosphorylation of RIPK1 & RIPK3 and leads to the activation of the mixed lineage kinase domain-like protein (MLKL) and cell lysis. Our previous work ...
中文名称:人混合谱系激酶域样蛋白(MLKL)ELISA试剂盒 中文同义词:人混合谱系激酶域样蛋白(MLKL)ELISA试剂盒 英文名称:Human mixed lineage kinase domain-like protein (MLKL) ELISA kit 英文同义词: CAS号: 分子式: 分子量:0 EINECS号: 信息错误报告
Recent data implicate pseudokinases as key regulators of bona fide protein kinases within the cell, and demonstrate that mutations affecting pseudokinase domains underlie a number of human diseases, including polycythemia vera and Peutz-Jeghers Syndrome. Despite their emergence as essential signalling ...
BIOLOGICAL evolutionMETAZOAIn mammals, mixed lineage kinase domain-like protein (MLKL) is the executor of necroptosis. MLKL comprises an N-terminal domain (NTD), which alone suffices to trigger necroptosis by forming pores in the plasma membrane, and a C-terminal domain that inhibits the NTD ...