These findings suggest that noroviruses have acquired a host MLKL-like pore-forming domain to facilitate viral egress by inducing mitochondrial dysfunction.doi:10.1038/s41586-023-05851-wGuoxun WangDi ZhangRobert C. OrchardDustin C. HancksTiffany A. Reese...
We found that the norovirus-encoded NTPase NS3 contains an N-terminal four-helix bundle domain homologous to the membrane-disruption domain of the pseudokinase mixed lineage kinase domain-like (MLKL). NS3 has a mitochondrial localization signal and thus induces cell death by targeting mitochondria. ...
Mlkl, CT (Mlkl, Mixed lineage kinase domain-like protein) (APC) 基本信息更多信息 中文名称: Mlkl, CT (Mlkl, Mixed lineage kinase domain-like protein) (APC) 中文同义词: 英文名称: Mlkl, CT (Mlkl, Mixed lineage kinase domain-like protein) (APC) 英文同义词: Mlkl, CT (Mlkl, Mixed ...
Necroptosis is regulated by three key proteins: receptor-interacting serine/threonine-protein kinase (RIPK)-1, RIPK3, and mixed-lineage kinase domain–like protein (MLKL). Here, we found that marked steatosis of the liver was induced when a Western diet was given in mice; steatosis was ...
MEF mouse embryo fibroblast TRIF TIR domain-containing adapter-inducing interferon-β MLKL mixed lineage kinase domain-like protein. 3 P. J. Gough, C. Sehon, R. Marquis, and J. Bertin, manuscript in preparation. 4 E. Lien, University of Massachusetts, personal communication. ...
Mixed lineage kinase domain-like protein (Mlkl) was recently found to interact with receptor interacting protein 3 (Rip3) and to be essential for tumor nec... J Wu,Z Huang,J Ren,... - 《Cell Research》 被引量: 281发表: 2013年 A cellular screen identifies ponatinib and pazopanib as inh...
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et al. Norovirus MLKL-like protein initiates cell death to induce viral egress. Nature 616, 152–158 (2023). https://doi.org/10.1038/s41586-023-05851-w Download citation Received11 March 2022 Accepted15 February 2023 Published29 March 2023 Issue Date06 April 2023 DOIhttps://doi.org/10.1038...
Flow cytometry and immunofluorescence staining during a time course of atherosclerosis revealed a progressive decrease of splenic endothelial cells that was correlated with a reduction of MLKL endogenously or by Mlkl KD, suggesting that splenic MLKL modulates the endothelial cells known to regulate ...
RIP1, RIP3, and the mixed lineage kinase domain-like (MLKL) protein form a necrosis signaling complex named necrosome, within which MLKL is phosphorylated at T357 and S358 residues by RIP3 (Sun et al., 2012). MLKL is a pseudokinase that is able to bind RIP3 through its kinase-like ...