Mixed-lineage-leukemia (MLL) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation. Leukemia. 2009; 23 (12):2197–209. doi: 10.1038/leu.2009.177. [ Cross Ref ]Ono R, Kumagai H, Nakajima H, et al. Mixed-lineage-leukemia (MLL) ...
目的 应用常规细胞遗传学分析结合荧光原位杂交技术(双色FISH)检测累及单核系统急性髓性白血病(acute myeloid leukemia,AML)中混合细胞系白血病基因MLL(mixed lineage leukemia gene或称为ALL1基因或HRX基因)受累情况的表达,探讨MLL基因受累的检测在急性白血病分型诊断中的意义。4...
(2009) Impaired function of prim- itive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog MLL5. Blood 113: 1444–1454. doi: 10.1182/blood-2008-02-142638 PMID: 18952892 9. Yap DB, Walker DC, Prentice LM, McKinney S, Turashvili G, et al. (2011) Ml...
...酶DOT1L的小分子抑制剂,该抑制剂可选择性的杀死混合后裔白血病(mixed-lineage leukemia) 细胞。 blog.sciencenet.cn|基于2个网页 2. 混合谱系白血病 混合谱系白血病,mixed-lineage... ... )mixed-lineage leukemia混合谱系白血病) MLL 混合谱系白血病蛋白 ... ...
MLL ( myeloid / lymphoid or mixed lineage leukemia ) H Genes,L Solid,TC Deep,... 被引量: 6发表: 2002年 The critical role of chromosome translocations in human leukemias. One such gene is MLL (myeloid-lymphoid or mixed lineage leukemia) located at chromosome band 11q23. The target gene...
Acute myeloid and lymphoid leukemias often harbor chromosomal translocations involving the KMT2A gene, encoding the KMT2A lysine methyltransferase (also known as mixed-lineage leukemia-1), and produce in-frame fusions of KMT2A to other chromatin-regulato
Back when Sally was first diagnosed with ALL Leukemia, a lot of people said “thank god she has that and not the other one – AML Leukemia.” AML is considered much harder to treat. However Sally was also diagnosed with Mixed Lineage Leukemia (or MLL), which when first diagnosed, the ...
Mixed Lineage Leukemia Protein 来自 Springer 喜欢 0 阅读量: 41 作者: SB Heidelberg 展开 摘要: MLL protein; is a nuclear protein that binds DNA through its three AT-hooks. It is required for the regulation of HOX gene expression during development and hematopoiesis. The MLL gene is ...
英文名称:MLL2 (Myeloid/Lymphoid or Mixed-Lineage Leukemia 2, AAD10, ALR, CAGL114, MLL4, TNRC21) (APC) 英文同义词:MLL2 (Myeloid/Lymphoid or Mixed-Lineage Leukemia 2, AAD10, ALR, CAGL114, MLL4, TNRC21) (APC) CAS号: 分子式: ...
Mixed lineage leukemia 1 (MLL1, also known as MLL or KMT2A) is an important transcription factor and histone-H3 lysine-4 (H3K4) methyltransferase. It is a master regulator for transcription of important genes (e.g., Hox genes) for embryonic development and hematopoiesis. However, it is larg...