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Muntean, A. G. & Hess, J. L. The pathogenesis of mixed-lineage leukemia.Annu. Rev. Pathol.7, 283–301 (2012). ArticleCASGoogle Scholar Lim, D. A. et al. Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells.Nature458, 529–533 (2009). Arti...
The prognosis of acute leukaemias harbouring rearrangements of the gene lysine methyltransferase 2A (KMT2A), previously known as mixed-lineage leukaemia (MLL), is poor, with a 5-year overall survival of less than 25% (ref.7).KMT2Arearrangements (KMT2Ar) occur in 80% of infant acute lymp...
Premature ovarian failure (POF) has a profound impact on female reproductive and psychological health. In recent years, the transplantation of umbilical cord-derived mesenchymal stem cells (UC-MSCs) has demonstrated unprecedented potential in the treatme
adult T-cell leukemia/lymphoma (ATL) in 21 patients, chronic lymphocytic leukemia (CLL) in 25 patients, prolymphocytic leukemia (PLL) in 4 patients, non-Hodgkin’s lymphoma (NHL) in 47 patients, multiple myeloma (MM) in 6 patients, and mixed-lineage leukemia (mixed AL) in 10 patients. ...
Protein-protein interactions (PPIs) are central to a variety of biological processes, and their dysfunction is implicated in the pathogenesis of a range of human diseases, including cancer. Hence, the inhibition of PPIs has attracted significant attentio
Proteomics approaches that globally quantify changes in protein abundance and phosphorylation are powerful tools to elucidate mechanisms of viral pathogenesis by providing a snapshot of how cellular pathways and processes are rewired upon infection (Johnson et al., 2020). Importantly, the functional outco...
polymorphic variations in the promoter sequences of the Bax and Bcl-2 gene have been recently associated with low Bax expression, progression to advanced stages, treatment resistance, and shortened overall survival rate in some hematological malignancies, including chronic myeloid leukemia (CML) and oth...
Thus, oxidative stress is considered critical for the pathogenesis of osteoporosis [25,26]. Reports have shown that ramie leaves are a rich source of various bioactive compounds, including xanthins, benzoic acid, 4-coumaric acid, caffeic acid, ferulic acid, rutin, chlorogenic acid, etc. [6]....
[ 104 ]. such atl cells are thought to suppress the immune response via expression of immunoregulatory molecules on their surfaces, and production of immunosuppressive cytokines. 6. pathogenesis of htlv-i infection atl cells are derived from activated helper t-lymphocytes, which play central roles ...