Mixed phenotype acute leukemia (MPAL) is an uncommon type of leukemia. It is one kind of malignant clonal diseases that expresses more than one genealogical specific antigen simultaneously. Most MPAL patients are associated with clonal chromosomal abnormalities and molecular genetic changes, such as ...
What is mixed-phenotype acute leukemia? Patients diagnosed with acute leukemia (>20% blasts in blood or marrow, or fewer in the case of certain chromosomal translocations or an extramedullary presentation) can generally be classified as having either myeloid lineage–derived disease (AML) or lymphoid...
Chronic Myeloid Leukemia: Modern therapies, current challenges and future directions - ScienceDirect Without effective therapy, CP-CML invariably progresses to blast phase (BP-CML), an acute leukemia of myeloid or lymphoid phenotype. The development of ... AEG Osman,MW Deininger - 《Blood Reviews...
The first case was an 8-year-old boy with acute mixed leukemia in whom... Yamashita,Umemura,Sadamura,... - 《Acta Haematologica》 被引量: 3发表: 1996年 B/T mixed phenotype acute leukemia with high hyperdiploidy and lineage switch to B-cell acute leukemia Acute leukemias are often of ...
The majority of cases of acute leukemia belong to a specific lineage origin, either lymphoid or myeloid, and therefore are classified as acute lymphoblastic leukemia (ALL) or acute myelogenous leukemia (AML), based on morphologic features and cytochemical and immunophenotypic profile of the blast cel...
The rarity of mixed-phenotype acute leukemia (MPAL) has resulted in diffuse literature consisting of small case series, thus precluding a consensus treatment approach. We conducted a meta-analysis and systematic review to investigate the association of treatment type (acute lymphoblastic leukemia [ALL...
Using this approach, we establish a normal epigenetic baseline for healthy blood development, which we then use to deconvolve aberrant molecular features within blood from patients with mixed-phenotype acute leukemia4,5. Despite widespread epigenetic heterogeneity within the patient cohort, we observe ...
Using this approach, we establish a normal epigenetic baseline for healthy blood development, which we then use to deconvolve aberrant molecular features within blood from patients with mixed-phenotype acute leukemia. Despite widespread epigenetic heterogeneity within the patient cohort, we observe common ...
A 69-year-old woman was diagnosed as having mixed phenotype acute leukemia. The patient received CBT for primary refractory disease. After preconditioning chemotherapy, the patient's condition deteriorated, leading to acute respiratory failure from capillary leak syndrome and consequent admittance to the...
ETV6 /FLT3 fusion in a mixed-phenotype acute leukemia arising in lymph nodes in a patient with myeloproliferative neoplasm with eosinophilia Niloufar Hosseini, Kenneth J. Craddock, Shabnam Salehi-rad, Shawn Brennan, Denis J. Bailey, Joseph M. Brandwein, Anna Porwit $39.95 / €34.95 ...