TreatmentGenomicsPurpose of Review Mixed phenotype acute leukemia (MPAL) is a rare subtype of acute leukemia with features of both acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). The review examines current definitions and controversies in classification of MPAL, new insights ...
Chronic Myeloid Leukemia: Modern therapies, current challenges and future directions - ScienceDirect Without effective therapy, CP-CML invariably progresses to blast phase (BP-CML), an acute leukemia of myeloid or lymphoid phenotype. The development of ... AEG Osman,MW Deininger - 《Blood Reviews...
We report two patients with acute leukemias who expressed two types of bcr/abl mRNA. The first case was an 8-year-old boy with acute mixed leukemia in whom... Yamashita,Umemura,Sadamura,... - 《Acta Haematologica》 被引量: 3发表: 1996年 B/T mixed phenotype acute leukemia with high hy...
The rarity of mixed-phenotype acute leukemia (MPAL) has resulted in diffuse literature consisting of small case series, thus precluding a consensus treatment approach. We conducted a meta-analysis and systematic review to investigate the association of treatment type (acute lymphoblastic leukemia [ALL...
Figure 3. The approach to therapy in patients with mixed-phenotype acute leukemia (MPAL). Targeted therapy based on a patient's specific genetic profile should be considered in refractory/relapse patients (eg, MLL rearrangements, FLT3-ITD, IDH1, IDH2). Case presentation: part 2 Based on immun...
The rarity of mixed phenotype acute leukemia (MPAL) has precluded adequate data to incorporate minimal residual disease (MRD) monitoring into therapy. Fluidity in MPAL classification systems further complicates understanding its biology and outcomes; this includes uncertainty surrounding the impact of ...
The pathogenicity of auto- and alloantibodies after ASCT, however, remains unproven, as transfer of antibodies between mice with and without cGVHD has not consistently transferred the disease phenotype in all models [67,68]. Rituximab as a treatment for cGVHD is discussed in greater detail in th...
Using this approach, we establish a normal epigenetic baseline for healthy blood development, which we then use to deconvolve aberrant molecular features within blood from patients with mixed-phenotype acute leukemia. Despite widespread epigenetic heterogeneity within the patient cohort, we observe common ...
Event-free survival is poor for RCM in childhood; however, the mixed RCM/HCM phenotype has significantly better event free survival. Both groups fare ... S Webber,SE Lipshultz,LA Sleeper,... 被引量: 2发表: 2008年 Age Related Changes in Adults with Acute Leukemia There are well known dif...
For example, AF4 fusions are more common in acute lymphoid leukemia (ALL), and AF9 fusions are associated with acute myeloid leukemia (AML)1. In addition, KMT2A rearrangements are also prevalent in mixed-phenotype acute leukemia (MPAL), and numerous examples of KMT2Ar leukemias that inter...