HMPL-506是一种研究性的新型、高选择性靶向menin蛋白的口服小分子抑制剂。Menin 蛋白是一种控制基因表达和细胞信号传递的支架蛋白。混合谱系白血病 (mixed-lineage leukemia, "MLL", 亦称KMT2A) 重排和核磷蛋白1 ("NPM1") 突变在急性髓系...
[2]1 Microenvironment Determines Lineage Fate in a Human Model of MLL-AF9 Leukemia. Junping Wei,Mark Wunderlich et,2008 [3] The prognostic value of MLL-AF9 detection in patients with t(9;11)(p22;q23)-positive acute myeloid leukemia. Claudia Scholl et...
Walker H,Wheatley K,Bowen D T,Burnett A K,Goldstone A H,Linch D C. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854...
NK cells play a significant role in immunosurveillance at the early stage of MLL-AF9 acute myeloid leukemia via CD226/CD155 interactions. China Life Sci., 58: 1288-1298. DOI: 10.1007/s11427-015-4968-3Wang Y, Chen C, Dong F, Ma S, Xu J, Gong Y, Cheng H, Zhou Y, Cheng T, Hao...
BACKGROUND: Mixed lineage leukemia (MLL) gene rearrangements in AML patients always had very poor prognosis. In this study, Reported that the incidence of rearrangements in patients with acute myeloid leukemia MLL gene analysis of clinical significance and prognostic features. ...
Chromosomal rearrangements of the human MLL/KMT2A gene are associated with infant, pediatric, adult and therapy-induced acute leukemias. Here we present the data obtained from 2345 acute leukemia patients. Genomic breakpoints within the MLL gene and the
本次APBMT大会上,高博医学(血液病)北京研究中心北京高博博仁医院吴彤主任、赵永强医生团队王睿医生报告了“Allogeneic Hematopoietic Stem Cell Transplantation Improves the Poor Prognosis in MLL-AF6 Positive Acute Myeloid Leukemia”(allo-HSCT改善MLL-AF6阳性AML患者不良预后),【摘要号187】。
HMPL-506是一种研究性的新型、高选择性靶向menin蛋白的口服小分子抑制剂。Menin 蛋白是一种控制基因表达和细胞信号传递的支架蛋白。混合谱系白血病 (mixed-lineage leukemia, "MLL", 亦称KMT2A) 重排和核磷蛋白1 ("NPM1") 突变在急性髓系白血病 (acute myeloid leukemia, AML) 中起关键作用。成人急性髓系白血病...
Early clinical data have demonstrated an antitumor effect of small molecule inhibitors directed at interactions of menin, a tumor suppressor protein, and MLL fusion proteins in acute myeloid leukemia (AML).2 One such agent, KO-539, is being investigated in 2 genetic subsets of AML: patients wit...
本次APBMT大会上,高博医学(血液病)北京研究中心北京高博博仁医院吴彤主任、赵永强医生团队王睿医生报告了“Allogeneic Hematopoietic Stem Cell Transplantation Improves the Poor Prognosis in MLL-AF6 Positive Acute Myeloid Leukemia”(allo-...