Inflammatory recruitment of healthy hematopoietic stem and progenitor cells in the acute myeloid leukemia niche Ding-Wen Chen Jian-Meng Fan Peter Kurre Leukemia(2024) Molecular Deconvolution of Bone Marrow Adipose Tissue Interactions with Malignant Hematopoiesis: Potential for New Therapy Development ...
Little is known about how leukemia cells alter the bone marrow (BM) niche to facilitate their own growth and evade chemotherapy. Here, we provide evidence that acute myeloid leukemia (AML) blasts remodel the BM niche into a leukemia growth-permissive and
Acute myeloid leukemia (AML) is a heterogeneous group of disorders defined by the proliferation of immature hematopoietic elements. The prototypical disease is characterized by an expansion of immature myeloid cells (myeloblasts) to comprise 20% or greater of the bone marrow or peripheral blood hema...
Acute Myeloid Leukemia (AML) is a bone marrow malignancy characterized by the infiltration of the bone marrow, blood and other tissues by clonal cells of the myeloid lineage with limited or no potential for differentiation [1]. From: Leukemia Research, 2022 ...
Acutemyeloidleukemia(AML)•isamalignanthematologicaldisorder•thebonemarrowmakesabnormalmyeloblasts—precursoroferythrocyte,plateletandgranulocyte•clonalproliferationofmyeloidprecursorcellswithreducedcapacitytodifferentiateintomorematurecells.Normally,thebonemarrowmakesbloodstemcells(immaturecells)thatdevelopintomatureblood...
Acute myeloid leukemia (AML) is a cancer that starts in the cells of your bone marrow that make different types of blood cells. It usually starts in a precursor cell to one type of white blood cell. Many of the symptoms of AML are nonspecific, which means they can be caused by several...
250-254.0 Munksgaard1998. Intestinalpermeabilitywasstudiedinpatientswithacutemyeloidleukemia (AML)before,duringandafterchemotherapy.Intestinalpermeabilitywas determinedbythelactulose(La)/mannitol(Ma)absorptiontestin16adult patientswithdenowAML.Thehydrogenbreathtestwasusedtodisclose bacterialfermentationofthetestsubstancesin...
et al. Subtype-specific regulatory network rewiring in acute myeloid leukemia. Nat. Genet. 51, 151–162 (2019). Article CAS PubMed Google Scholar McKeown, M. R. et al. Superenhancer analysis defines novel epigenomic subtypes of non-APL AML, including an RARα dependency targetable by SY-...
Nonrandom chromosomal abnormalities present at the time of diagnosis of acute myeloid leukemia (AML) are used to direct treatment decisions for patients as they are known predictors of response to therapy and disease-free and overall survival. During recent years, molecular analyses have revealed a ...
Guidelines on the initial diagnostic workup of acute leukemia (AL) have been issued by the College of American Pathologists and the American Society of Hematology (CAP/ASH). [118] Guidelines for the management of acute myeloid leukemia (AML) have been issued by the following organizations: Nat...