In seeming contrast to its tumor suppressor function, menin has an oncogenic function in hematopoietic cells in association with the MLL (mixed-lineage leukemia) histone methyltransferase complex (HMT), also functioning as part of COMPASS (complex proteins associated with SET1). FBP1 is an interact...
et al. Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression. Genes Dev. 20, 2397–2409 (2006). CAS PubMed PubMed Central Google Scholar Capotosti, F., Hsieh, J. J. & Herr, W. Species selectivity of mixed-lineage leukemia/Trithorax and HCF ...
V. et al. Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature 442, 818–822 (2006). Article CAS PubMed Google Scholar Bernt, K. M. et al. MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. Cancer Cell 20, 66–78 (...
Normal karyotype acute myeloid leukemia (NK-AML) constitutes 20–25% of pediatric AML and detailed molecular analysis is essential to unravel the genetic background of this group. Using publicly available sequencing data from the TARGET-AML initiative, w
Looking for online definition of FFFF or what FFFF stands for? FFFF is listed in the World's most authoritative dictionary of abbreviations and acronyms
RTP RTP&T RTP/IP RTP/UDP RTP4CS RTPA RTPAN RTPB RTPC RTPCB RTPCC RTPCR RTPCRB RTPD RTPE RTPF RTPG RTPH RTPHA RTPI RTPID RTPIS RTPK RTPL RTPLRS RTPM RTPMS RTPN RTPO RTPOZ RTPP RTPR RTPS RTPT RTPU RTPV RTQ ▼
In seeming contrast to its tumor suppressor function, menin has an oncogenic function in hematopoietic cells in association with the MLL (mixed-lineage leukemia) histone methyltransferase complex (HMT), also functioning as part of COMPASS (complex proteins associated with SET1). FBP1 is an interact...
is that there is not yet strong evidence that super-enhancers are a novel paradigm in gene regulation and that use of the term in this context is not currently justified. However, the term likely identifies strong enhancers that exhibit behaviors consistent with previous models and concepts of ...
single nucleotide polymor phism; UPD, uniparental disomy; MDS, myelodysplastic syndrome; AML acute myeloid leukemia; DLRS, derivative log ratio spread; ASCN, allele-specific copy number; IL, interleukin; MLL mixed-lineage leukemia; CBFB, core-binding factor, [beta] subunit; LOH, loss of heteroz...
is that there is not yet strong evidence that super-enhancers are a novel paradigm in gene regulation and that use of the term in this context is not currently justified. However, the term likely identifies strong enhancers that exhibit behaviors consistent with previous models and concepts of ...