Since the timely removal of abnormal mitochondria is essential for cell survival, cells have evolved a variety of mitophagy pathways to ensure that mitophagy can be activated in time under various environments. A better understanding of the mechanism of mitophagy in various diseases is crucial for ...
Recently, there has been a better understanding of how mitophagy is regulated. Preliminary research progress has been made in the mechanistic link between mitophagy and disease and the application of mitochondrial regulators to treat diseases in animal models.3,4,6However, few articles summarize how ...
In this Review, we describe the basic mechanisms of mitophagy and how mitophagy can be assessed in human blood, the immune system and tissues, including muscle, brain and liver. We outline mitophagy’s role in specific diseases and describe mitophagy-activating approaches successfully tested in ...
Emerging role of mitophagy in human diseases and physiology Mitophagy is a process of selective removal of damaged or unnecessary mitochondria using autophagic machinery. Mitophagy plays an essential role in maintai... Um, Jee-Hyun,J Yun - 《Bmb Reports》 被引量: 4发表: 2017年 Mitophagy ...
Mitophagy in human diseasesInt. J. Mol. Sci.10.3390/ijms22083903 Doblado, L., Lueck, C., Rey, C., Samhan-Arias, A.K., Prieto, I., Stacchiotti, A.et al. (2021) . 22, 3903 Google Scholar 194. Cellular mitophagy: mechanism, roles in diseases and small molecule pharmacological regulat...
When the mitochondria are dysfunctional or their transport processes are blocked, axons become susceptible to degeneration triggered by energy depletion, resulting in neurodegenerative diseases. As the final checkpoint for mitochondrial quality control, axonal mitophagy is vital for neuronal growth, ...
Since the timely removal of abnormal mitochondria is essential for cell survival, cells have evolved a variety of mitophagy pathways to ensure that mitophagy can be activated in time under various environments. A better understanding of the mechanism of mitophagy in various diseases is crucial for ...
PTEN-induced kinase-1 (PINK1), a serine/threonine kinase, has been extensively studied in autosomal recessive familial Parkinson’s disease (PD) [29]. However, emerging evidence indicates that PINK1 has roles in other human diseases, such as cancers [30]. In breast cancer, Yaghoobi et al. ...
diseases,including neurological,cardiovascular,pulmonary,hepatic,renal disease,etc.,in recent advances.Finally,we summarize the potential clinical applications and outline the conditions for mitophagy regulators to enter clinical trials.Research advances in signaling transduction of mitophagy will have an ...
PTEN-induced kinase-1 (PINK1), a serine/threonine kinase, has been extensively studied in autosomal recessive familial Parkinson’s disease (PD) [29]. However, emerging evidence indicates that PINK1 has roles in other human diseases, such as cancers [30]. In breast cancer, Yaghoobi et al. ...