et al. Transcriptome analysis of human heart failure reveals dysregulated cell adhesion in dilated cardiomyopathy and activated immune pathways in ischemic heart failure. BMC Genomics 19, 812 (2018). CAS Google
Overview of the major mitophagy pathways The regulatory mechanisms of mitophagy have been mainly divided into ubiquitin-dependent and ubiquitin-independent or receptor-mediated mitophagy. In the following section, we focus on the various regulatory pathways of mitophagy. Ubiquitin-dependent mitophagy Traditio...
Mitophagy pathways in health and disease J. Cell Biol., 219 (2020), p. 10.1083/jcb.202004029 Google Scholar 7. Sun N., Yun J., Liu J., Malide D., Liu C., Rovira , Holmström K. M., Fergusson M. M., Yoo Y. H., Combs C. A., Finkel T. Measuring In Vivo Mitophagy Mol...
Alzheimer's disease (AD) is an age-dependent, incurable mental illness that is associated with the accumulation of aggregates of amyloid-beta (A尾) and hyperphosphorylated tau fragments (p-tau). Detailed studies on postmortem AD brains, cell lines, and mouse models of AD have shown that ...
D’Arcy, M.S. Mitophagy in health and disease. Molecular mechanisms, regulatory pathways, and therapeutic implications.Apoptosis29, 1415–1428 (2024). https://doi.org/10.1007/s10495-024-01977-y Download citation Accepted03 May 2024 DOIhttps://doi.org/10.1007/s10495-024-01977-y ...
The influence of the mitochondrial control system on ischemic heart disease has become a major focus of current research. Mitophagy, as a very crucial part of the mitochondrial control system, plays a special role in ischemic heart disease, unlike mitoch
HSPD1 is classically described as a mitochondrial protein with multiple roles in health and disease [52–54], participating in the maintenance of protein homeostasis. The eukaryotic HSPD1 belongs to chaperonins group I that assists with the correct folding of mitochondrial proteins [55], together...
A future for remote ischaemic conditioning in high-risk patients Source: Basic Research in Cardiology Vascular autophagy in health and disease Source: Basic Research in Cardiology Mitochondrial quality control in cardiac microvascular ischemia-reperfusion injury: New insights into the mechanisms and therapeut...
Here, the authors show that mitochondrial hyperfusion blunts mitophagy during the disease process, and that rescuing this process pharmacologically confers retinal neuroprotection independent of an improved glycaemic status in type-1 diabetic mice. Aidan Anderson , Nada Alfahad & Jose R. Hombrebueno ...
Ubiquitin-dependent pathways Currently, PINK1/Parkin-driven mitophagy is the most characterized pathway. In normal mitochondria, PINK1 is continuously imported into the inner membrane of the mitochondria and then cleaved by the mitochondrial proteases MPP and PARL [16,17]. However, in the context of...