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Here, the authors show that suppression of IP3R activity via inhibiting CISD1 is sufficient to rescue the PD-related phenotypes in PINK1 or Parkin null animal models. Su Jin Ham , Heesuk Yoo & Jongkyeong Chung Article 24 May 2023 | Open Access Phospholipase D3 degrades mitochondrial ...
Autophagic flow decreased in T cells after cecal ligation surgery (animal model of sepsis) for 24 h, and deficient autophagy or mitophagy via knocking out key autophagic molecules causes abnormal differentiation and apoptosis in T cells, natural killer cells [112,113,114]. Mitophagy survives ...
However, many of the genes that control mitophagy in yeast and animal cells are absent from plants, and no plant proteins marking defunct mitochondria for autophagic degradation are yet known. New insights implicate general autophagy-related proteins in mitophagy, affecting the senescence of plant ...
Cellular and animal models of TDP-43 and FUS depletion, as well as samples from ALS spinal cord, showed a decrease in the RNA level of Parkin, suggesting a possible increased vulnerability to mitochondrial dysfunction (Lagier-Tourenne et al., 2012; Polymenidou et al., 2011). The ...
[84]. Hypoxia acclimation with a low-pressure hypoxic animal chamber alleviated cardiac dysfunction and fibrosis caused by MI injury in mice through activation of FUNDC1-mediated mitophagy [92]. The role of FUNDC1 in ischemia/reperfusion injury in the heart is discussed further later in this ...
Here, we provide evidence that PINK1/Parkin-mediated mitophagy is impaired in the hippocampus of AD patients, in induced pluripotent stem cell-derived human AD neurons, and in animal AD models, that impaired removal of defective mitochondria is a pivotal event in AD pathogenesis and that mitophagy...
protein is only partially required for macroautophagy, such as mitophagy, and is not essential for basal autophagy or autophagy induced by nutritional deprivation [70]. Furthermore, the PINK1/Parkin pathway is not affected in the HD animal model, but the fusion of mitochondria with autophagosomes...
Recently, there has been a better understanding of how mitophagy is regulated. Preliminary research progress has been made in the mechanistic link between mitophagy and disease and the application of mitochondrial regulators to treat diseases in animal models.3,4,6However, few articles summarize how ...
We introduce an animal model in which two separate mutations act synergistically to produce severe ON degeneration. The first mutation is in Cryba1, which encodes 尾A3/A1-crystallin, a lens protein also expressed in astrocytes, where it regulates lysosomal pH. The second mutation is in Bckdk, ...