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Here, the authors show that suppression of IP3R activity via inhibiting CISD1 is sufficient to rescue the PD-related phenotypes in PINK1 or Parkin null animal models. Su Jin Ham , Heesuk Yoo & Jongkyeong Chung Article 24 May 2023 | Open Access Phospholipase D3 degrades mitochondrial ...
Under different conditions, mitophagy can exert completely paradoxical regulatory functions even in the same cell lines or animal models in OC. On the one hand, mitophagy maintains cellular mitochondrial homeostasis, promotes cell survival, and leads to resistance to chemotherapy; on the other hand, ...
Furthermore, existing literature indicates that various small molecule autophagy regulators have been tested in animal models and are linked to neurological disease outcomes. This review explores the role of mitophagy in programmed neuronal death and its connection to neuroinflammation.Yanlin Z...
However, many of the genes that control mitophagy in yeast and animal cells are absent from plants, and no plant proteins marking defunct mitochondria for autophagic degradation are yet known. New insights implicate general autophagy-related proteins in mitophagy, affecting the senescence of plant ...
Cellular and animal models of TDP-43 and FUS depletion, as well as samples from ALS spinal cord, showed a decrease in the RNA level of Parkin, suggesting a possible increased vulnerability to mitochondrial dysfunction (Lagier-Tourenne et al., 2012; Polymenidou et al., 2011). The ...
Tong BC, Huang AS, Wu AJ, Iyaswamy A, Ho OK, Kong AH, Sreenivasmurthy SG, Zhu Z, Su C, Liu J al (2022) Tetrandrine ameliorates cognitive deficits and mitigates tau aggregation in cell and animal models of tauopathies. J Biomed Sci 29:85. https://doi.org/10.1186/s12929-022-00871-...
[84]. Hypoxia acclimation with a low-pressure hypoxic animal chamber alleviated cardiac dysfunction and fibrosis caused by MI injury in mice through activation of FUNDC1-mediated mitophagy [92]. The role of FUNDC1 in ischemia/reperfusion injury in the heart is discussed further later in this ...
Tong BC, Huang AS, Wu AJ, Iyaswamy A, Ho OK, Kong AH, Sreenivasmurthy SG, Zhu Z, Su C, Liu J al (2022) Tetrandrine ameliorates cognitive deficits and mitigates tau aggregation in cell and animal models of tauopathies. J Biomed Sci 29:85. https://doi.org/10.1186/s12929-022-00871-...
All procedures involving PGC-1α KO and corresponding wild-type (WT) animals were approved by and conducted in accordance with the regulations of the York University Animal Care Committee in compliance with the guidelines set forth by the Canadian Council on Animal Care. All PGC-1α Tg and ...