2022年有研究者在RA患者的血浆外泌体中发现新的外泌体miRNA分子,并且该研究显示血浆外泌体miR-204-5p表达与RA患者疾病参数呈负相关。这些外泌体可以转移至滑膜成纤维细胞中,抑制细胞活化与增殖。该研究进一步进行了动物体内试验,发现注射过表达 miR-204-5p 的慢...
本发明提供的包载miRNA2045p的外泌体,显著提高与肿瘤细胞的相容性,能够高效将miRNA2045p释放进入肿瘤细胞内,增加肿瘤细胞对化疗药物的敏感性,显著抑制肿瘤细胞的增殖.通过模拟体内情况,优选操作过程中使用的试剂种类,质量或者浓度等参数,在细胞内将miRNA2045p自然装载到外泌体中,显著提高miRNA2045p与外泌体在细胞内...
过表达miR-204-5p可显著提高缩足反应阈值和缩足潜伏期;③在坐骨神经慢性缩窄性损伤大鼠和脂多糖激活的HAPI细胞中,过表达miR-204-5p可以抑制炎性细胞因子的分泌;④双荧光素酶报告基因证实了AURKB是miR-204-5p的下游靶基因;⑤在坐骨神经慢性缩窄性损伤大鼠背根神经节中,AURKB mRNA表达显著升高...
Tumor suppressor miRNA-204-5p promotes apoptosis by targeting BCL2 in prostate cancer cells. Asian J Surg. 2017;40(5):396-406.Lin YC, Lin JF, Tsai TF, Chou KY, Chen HE, Hwang TI. Tumor suppressor miRNA-204-5p promotes apoptosis by targeting BCL2 in prostate cancer cells. Asian J ...
外泌体类风湿关节炎病理生理意义自身免疫性疾病关节损伤非编码RNA文献报道MIRNA类风湿关节炎(rheumatoid arthritis,RA)是一种自身免疫性疾病,其病因和发病机制复杂,外泌体来源的miRNA在RA炎症和关节损伤的发展中有关键作用,既往研究已经检测到数种与RA活动和缓解相关的非编码RNA的可变表达,如miR-155,miR-146等[1].近...
Disabling VEGF-Response of Purkinje Cells by Downregulation of KDR via miRNA-204-5pdoi:10.3390/IJMS22042173Julian GehmeyrAbdelouahid MaghnoujJonas TjadenMatthias VorgerdStephan HahnVeronika MatschkeVerena TheisCarsten TheissMultidisciplinary Digital Publishing Institute...
miRNA-204-5p commonly acts in the suppression of oncogenes in tumors. In this study, the levels of miRNA-204-5p were found to be down-regulated in the astrocytoma samples. miRNA-204-5p expression was also down-regulated in two astrocytoma cell lines (U87MG and LN382). Examination of ...
Dual-luciferase reporter assays in LECs were conducted to verify whether miRNA-204-5p was negatively regulated by MALAT1 and Smad4 was a direct target of miR-204-5p.Results The expression of MALAT1 was upregulated in PCO specimens. MALAT1 was overexpressed in TGF-β2 induced LECs, and the...