2022年有研究者在RA患者的血浆外泌体中发现新的外泌体miRNA分子,并且该研究显示血浆外泌体miR-204-5p表达与RA患者疾病参数呈负相关。这些外泌体可以转移至滑膜成纤维细胞中,抑制细胞活化与增殖。该研究进一步进行了动物体内试验,发现注射过表达 miR-204-5p 的慢...
过表达miR-204-5p可显著提高缩足反应阈值和缩足潜伏期;③在坐骨神经慢性缩窄性损伤大鼠和脂多糖激活的HAPI细胞中,过表达miR-204-5p可以抑制炎性细胞因子的分泌;④双荧光素酶报告基因证实了AURKB是miR-204-5p的下游靶基因;⑤在坐骨神经慢性缩窄性损伤大鼠背根神经节中,AURKB mRNA表达显著升高...
本发明提供的包载miRNA2045p的外泌体,显著提高与肿瘤细胞的相容性,能够高效将miRNA2045p释放进入肿瘤细胞内,增加肿瘤细胞对化疗药物的敏感性,显著抑制肿瘤细胞的增殖.通过模拟体内情况,优选操作过程中使用的试剂种类,质量或者浓度等参数,在细胞内将miRNA2045p自然装载到外泌体中,显著提高miRNA2045p与外泌体在细胞内...
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Dual-luciferase reporter assays in LECs were conducted to verify whether miRNA-204-5p was negatively regulated by MALAT1 and Smad4 was a direct target of miR-204-5p. Results: The expression of MALAT1 was upregulated in PCO specimens. MALAT1 was overexpressed in TGF-尾2 induced LECs, and ...
外泌体类风湿关节炎病理生理意义自身免疫性疾病关节损伤非编码RNA文献报道MIRNA类风湿关节炎(rheumatoid arthritis,RA)是一种自身免疫性疾病,其病因和发病机制复杂,外泌体来源的miRNA在RA炎症和关节损伤的发展中有关键作用,既往研究已经检测到数种与RA活动和缓解相关的非编码RNA的可变表达,如miR-155,miR-146等[1].近...
miRNA-204-5pColon cancerMesoporous silica nanoparticlesAntitumor efficacyMain purpose of present study was to enhance the therapeutic efficacy in the treatment of colon adenocarcinoma by combining the benefits of chemotherapy and gene therapy. In this study, we have successfully formulated oxaliplatin (OXL...
We confirmed the down-regulation of lncRNA-Neat1, lncRNA-Snhg5 and lncRNA-Gm9926 and the up-regulation of miRNA-204-5p, miRNA-218-5p, miRNA-200a-3p and miRNA-466h-5p. Additionally, the decreased expression level of the AKT3, p-AKT3, PI3K, p-PI3K protein were confirmed.Conclusions...
Disabling VEGF-Response of Purkinje Cells by Downregulation of KDR via miRNA-204-5pdoi:10.3390/IJMS22042173Julian GehmeyrAbdelouahid MaghnoujJonas TjadenMatthias VorgerdStephan HahnVeronika MatschkeVerena TheisCarsten TheissMultidisciplinary Digital Publishing Institute...
miRNA-204-5p commonly acts in the suppression of oncogenes in tumors. In this study, the levels of miRNA-204-5p were found to be down-regulated in the astrocytoma samples. miRNA-204-5p expression was also down-regulated in two astrocytoma cell lines (U87MG and LN382). Examination of ...