另外,miR-126-3p和miR-145-5p在血管免疫母T细胞淋巴瘤(AITL)中具有预后相关性,为其不良预后标志物。 从研究摘要一览文章设计和结论 研究目的:外周T细胞淋巴瘤(PTCL)侵袭性程度高,且具有极大的疾病异质性。该研究小组对PTCL的miRNA表...
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MiRNA-145-5p inhibits gastric cancer progression via the serpin family E member 1-extracellular signal-regulated kinase-1/2 axisGastric cancerMicroRNA-145-5pSerpin family E member 1Epithelial-mesenchymal transitionProliferationExtracellular signal-regulated kinase-1/2...
miR-145-5p.The mechanism by which miR-145-5p influences GC progression was further explored by assessing tumor formation in nude mice.RESULTS GC tissues and cells had reduced miR-145-5p expression and SERPINE1 was identified as a direct target of this miRNA.Overexpression of miR-145-5p was ...
在CGN大鼠中有26个差异表达的miRNA参与CGN的发病与发展,其中miR-145-5p与真武汤在LPS刺激系膜细胞产生炎症应答中起重要调控作用相似,均可以上调IL-10的表达,通过抑制PI3K/AKT/GSK信号通路参与炎症因子分泌的负反馈调节.3.miR-145-5p和真武汤还可以通过降低Cyclin D1的表达,抑制MC的异常增殖;抑制NF-KappaB的活化,...
将本发明所述的microRNA145-5p修饰的脐带间充质干细胞分泌的外泌体用于大鼠背部全层皮肤缺损创面模型以检验其是否促进创面愈合及拮抗瘢痕增生。 本发明经实验证明,以miRNA145-5p修饰的脐带间充质干细胞的外泌体具有加快创面愈合速度并同时可以抑制瘢痕过度增生的表现,为修饰过后的外泌体用于临床治疗创伤开辟新的途径。
本发明的外泌体是通过以下方法制备:(1)采用新鲜脐带培养人脐带间质干细胞;(2)制备高表达miRNA145-5p的间充质干细胞;(3)条件培养基的储备;(4)外泌体的抽提与纯化.本发明所述的高表达microRNA145-5p的人脐带间充质干细胞来源的外泌体作为生物制剂转入大鼠背部全层创面模型中可有效促进皮肤肉芽组织增生,加快...
Results: AngII incubation induced an upregulation of miR-145-5p and inflammatory factors including Intercellular Adhesion Molecule 1 (ICAM-1), Interleukin 6 (IL-6), Interleukin 8 (IL-8), and Interleukin 1尾 (IL-1尾). Additionally, it elevated the expression of ...
miRNA-145-5pmiRNA-124-3pLong noncoding RNA (lncRNAs) UCA1 has been known to be critical for the chondrogenic differentiation of marrow mesenchymal stem cells (MSCs). In this study, we explore the effects and mechanisms of UCA1 on the promotion of chondrogenesis of MSCs. During the processes...