miRNA-155-5pRadiation-induced pulmonary fibrosisEMTGSK-3 betaNF-kappa BRadiation-induced pulmonary brosis (RIPF) is a major lung complication in using radiotherapy to treat thoracic diseases. MicroRNAs (miRNAs) are reported to be the therapeutic targets for many diseases. However, the miRNAs ...
结果与miR-NC组比较,miRNA155-5p过表达组p38 MAPK,JNK和ERK mRNA表达水平明显升高(P<0.01).与模型组比较,Uro A能明显抑制LPS诱导的miRNA155-5p,NO,PGE 2和TNF-α,IL-1β,IL-6(P<0.01),降低iNOS,COX-2蛋白表达水平(P<0.01),且呈浓度依赖性;此外,Uro A明显抑制TLR4蛋白的表达水平以及p38 MAPK,JNK,NF...
目的对社区居民的亚健康状态及其主要危险因素进行评价,并从表观遗传因素方面初步探讨外周血单个核细胞中miR-125a-5p、miR-155、miR-21及miR-133a与亚健康状态的关系,为有针对性地预防社区居民亚健康状态、深入探讨亚健康状态的表观遗传因素及机制提供理论依据。方法于2014年4~9月期间,选择福建省福清市、长乐市和泉...
However, studies investigated whether miRNA155-5P targeted DDX3X to attenuate pyroptosis were scarce. Results: The expression of pyroptosis-related proteins (caspase-1, interleukin-1 (IL-1), NOD-like receptor family pyrin domain containing 3 (NLRP3), and IL-18) were up-regulated in the IRI ...
miRNA-155–5pRadiation-induced pulmonary fibrosisEMTGSK-3βNF-κBRadiation-induced pulmonary brosis (RIPF) is a major lung complication in using radiotherapy to treat thoracic diseases. MicroRNAs (miRNAs) are reported to be the therapeutic targets for many diseases. However, the miRNAs involved in...
This study aimed to evaluate the expression profiles of sera miRNA-208a-3p, miRNA-155-5p, and miRNA-637, to examine relation to osteoporosis and suggest the possible mechanisms of action to be used as innovative biomarkers for the diagnosis of osteoporosis among pre- and postmenopausal females....
腺性膀胱炎LncRNAGCAT1PTENmiR-155-5p研究背景腺性膀胱炎(Glandular Cystitis,GC)是一种易复发的膀胱炎症性疾病,病理表现为移行上皮的增生与化生.GC的症状主要以尿路刺激症以及血尿为主,严重影响患者的生活质量与身心健康.GC曾经被认为发病率较低,但随着膀胱镜的普及,病理活检的增加,GC的检出率不断升高,影响范围...
本发明具体公开了一种hsa‑miRNA‑155‑5p(简称miR‑155)在制备抑制肠道病毒71型(简称EV71)药物中的用途。本发明利用分子生物学技术发现EV71感染细胞后,能使胞内的miR‑155表达升高。miR‑155可通过靶向磷脂酰肌醇网格蛋白装配蛋白PICALM,进而抑制EV71的复制。本发明的上述应用为诊断和治疗EV71引发的疾病如...
脓毒症急性肺损伤IKKα/NF-κB通路抑制氧化肺功能目的 探究miRNA-155-5P靶向TLR4基因对脓毒症急性肺损伤大鼠的干预效果.方法 48只SPF级SD大鼠,分为空白组,模型组,过表达组,沉默组各12只,空白组不做任何处理,模型组,过表达组,沉默组构建脓毒症急性肺损伤大鼠模型,做miRNA-155-5P慢病毒滴定,分别进行干预.实时...
目的探讨miRNA155-5p在异基因造血干细胞移植后口腔慢性移植物抗宿主病(chronic graft versus host disease,cGVHD)患者血浆中的表达水平及意义.方法选取异基因造血干细胞移植后确诊为口腔cGVHD的患者18人纳入口腔cGVHD组,异基因造血干细胞移植后没有出现口腔cGVHD的患者18人为无口腔cGVHD组,对照组纳入健康者18人.收集三...