miRNA-21：miRNA-21是一种microRNA，是一种非编码RNA，通常包括两个不同的成熟miRNA，即miRNA-21-5p...
miRNA-21-5pThe incidence of laryngeal carcinoma accounts for 1 to 5% of systemic malignancies and ranks second among head and neck malignancies. Screening more effective targets are meaningful for the treatment of laryngeal carcinoma. The purpose was to research the action of miR-21-5p in the ...
miRNA是一类小非编码RNA,在RNA沉默中起指导分子的作用。miRNA以大多数蛋白质编码转录本为靶标,几乎参与了所有发育和病理过程。hsa-miR-21-5p是最具代表性的miRNA生物标志物。 hsa-miR-21-5p作为典型的onco-miRNA,它能够调节多种癌症相关的靶基因,如脑癌,肺癌,结肠直肠癌,胰腺癌,乳腺癌,胃癌,食管癌和肝细胞癌等...
目的通过将miRNA-21-5p转染到成骨细胞MV3T3-E1中,检测不同转染浓度及转染时间转染成骨细胞后miRNA-21-5p含量的变化,同时检测转染后成骨细胞分化蛋白:骨钙蛋白,P1NP和RUNX2含量的变化;同时检测不同时间和转染浓度转染成骨细胞MV3T3-E1后成骨细胞外基质矿化程度,从而揭示miRNA-21-5p与成骨细胞分化和矿化的相关性,...
In conclusion, the up-regulation of miR-21-5p in all patient groups indicating that miR-21-5p can help in the diagnosis of GD and its progression to orbitopathy, miR-21-5p also considered an important molecular target for GD therapy.
(P<0.05),其中恶性结节组在右肺上叶的发生率最高(48.89%).两组miRNA-21-5p和miRNA-574-5p水平比较,P<0.05,其中恶性结节组更高.据ROC曲线分析,miRNA-21-5p和miRNA-574-5p诊断恶性肺结节的AUC分别为0.690和0.711,联合AUC为0.819.结论 血清miRNA-21-5p和miRNA-574-5p在良恶性肺结节鉴别中诊断,具有较高的...
摘要 目的分析血清微小RNA(miRNA)-21-5p、miRNA-5189-5p表达水平对行腹腔镜根治性前列腺切除术(LRP)的老年前列腺癌患者预后的评估价值。方法选取2014年1月至2018年9月该院收治的行LRP治疗的2...展开更多 Objective To analyze the prognostic value of serum microRNA(miRNA)-21-5p and miRNA-5189-5p ...
摘要 目的基于miRNA21-5p调控转化生长因子-β1(transforming growth factor beta 1,TGF-β1)/Smads信号通路探讨苓桂气化方抗射血分数保留心力衰竭(heart failure ...展开更多 Objective To explore the anti-myocardial fibrosis mechanism of Linggui Qihua Formula(苓桂气化方,LGQH)based on miRNA21-5p regulating...
Micro-RNA-21-5p associated with the activity and severity of the disease and it could be used for follow up patients with AS and for assessment the response to biological treatments. 展开 关键词: miRNA-21-5p miRNA-146a-5p High sensitivity C- reactive protein (Hs-CRP) Ankylosing spondylitis ...
26a-5p,miR-21-5p,miR-191-5p的表达水平,使用ROC曲线分析血清miRNAs对AMI患者的诊断价值.结果 老年AMI患者miRNAs的表达水平相较于HCs下降1.8～2.0倍.2-ΔCt表达水平:miR-26a-5p[(0.62±0.34)vs.(1.24±0.63),P<0.001],miR-21-5p[(0.87±0.56)vs.(1.56±0.91),P<0.001],miR-191-5p[(0.99±0.51)vs....