UGT2A1 regulation may also be mediated by microRNA (miRNA). To identify miRNA important in the regulation of UGT2A1, expression analysis in tandem with in silico analysis suggested miR-196a-5p and miR-196b-5p as potential top candidates. Significant reductions in firefly luciferase activity ...
The miR-196a-5p- and miR-196b-55p-treated cells exhibited reductions of 35% (P = 0.047) and 44% (P = 0.0063), respectively. These data suggest that miR-196a-5p and miR-196b-5p play an important role in UGT2A1 regulation within the lung and potentially other aerodigestive tract ...
Results: miR-196-5p and miR-361-5p were, respectively, up- and down-regulated in COPD patients compared with healthy controls. Luciferase assays demonstrated that miR-361-5p and miR-196-5p were, respectively, targeting abca1 and arhgef12 3ʹUTR in BEAS-2B cells. GS significantly ...
Results: miR-196-5p and miR-361-5p were, respectively, up- and down-regulated in COPD patients compared with healthy controls. Luciferase assays demonstrated that miR-361-5p and miR-196-5p were, respectively, targeting abca1 and arhgef12 3ʹUTR in BEAS-2B cells. GS significantly ...
The aim of this study was to investigate the association of microRNA polymorphisms (miR-146aC>G,miR-149T>C,miR-196a2T>C, andmiR-499A>G) in Korean patients with recurrent implantation failure (RIF). We conducted a case–control study of 354 Korean women: 120 patients with RIF and 234...
esophageal squamous cell carcinoma, microRNA-196a, Annexin A1, cell proliferation, cell invasion, cell migrationMicroRNA (miR)-196a is upregulated in various types of malignancy, including esophageal squamous cell carcinoma (ESCC); however, its role in ESCC is currently unclear. The present study...
The anti-proliferation effect of GS was not observed in H292 cells. Conclusion: These findings indicate that miR-361-5p/abca1 and miR-196-5p/arhgef12 axis mediated GS inducing dual anti-proliferation effects on BECs.doi:10.2147/COPD.S326015Hui fen ShenYing LiuPing ping QuGuo liang Cheng...
MiR-361-5p/abca1 and MiR-196-5p/arhgef12 Axis Involved in γ-Sitosterol Inducing Dual Anti-Proliferative Effects on Bronchial Epithelial Cells of Chronic Obstructive Pulmonary Disease Hui-fen Shen, Ying Liu, Ping-ping Qu, Yu Tang, Bing-bing Li & Guo-liang Cheng Pages 2741-2753 | ...
《miR196a-NR6A1调节睾丸支持细胞连接及血睾屏障功能的作用机制》是依托湖南大学，由李丹担任项目负责人的面上项目。中文摘要 血睾屏障是以睾丸支持细胞及支持细胞与生精细胞间的连接为基础形成的结构，对其精细的调控是精子生成的保障。研究表明，TGFβ1是参与血睾屏障功能调节的重要细胞因子。在前...