MCE 国际站:hsa-miR-744-5p antagomir 产品活性:hsa-miR-744-5p antagomir 是一种经过特殊化学修饰的成熟miRNA的互补单链,全链进行甲氧基修饰,在5'端和3'端分别有2个和4个硫代骨架修饰,并在3'端连接有高亲和性胆固醇修饰。miRNA antagomir通过特异性结合成熟miRNA,阻止miRNA与其靶基因的互补配对,从而抑制miRNA...
通过生物信息学预测miR-744-5p的下游靶分子,qRT-PCR和Western blot验证CCND1在786-O及OSRC2细胞中的表达水平,双荧光素酶报告基因实验进一步验证miR-744-5p和CCND1的关系,最后通过回复实验验证miR-744-5p/CCND1轴在ccRCC中的作用。结果 MiR-744-5p在ccRCC组织和细胞系中显著下调(P<0.05),过表达miR-744-5p可以...
MiR-744-5p expression was reduced in the cancer cell lines independent of the host gene MAP2K4. Overexpression of miR-744-5p activated the intrinsic apoptotic pathway in SKOV3, OVCAR3 and Cisplatin resistant (A2780-cis) and non-resistant A2780 cells leading to cell death. Notably, miR-744...
在肺癌组中,早、晚期肺癌患者血清外泌体miR-744-5p的表达水平(0.011 7±0.013 9,0.012 6±0.021 2)与健康对照组相比,均明显降低(U=72.5,U=471.5,P均<0.001);肺腺癌外泌体miR-744-5p表达水平(0.010 6±0.020 3)低于肺鳞癌(0.017 3±0.017 8),差异具有统计学意义(U=394.5,P<0.001)。ROC曲线显示血清外...
miR-744-5p silencing promoted MM cells prolifera tion, invasion, migration, glucose uptake, lactate production, and EMT by elevating SOX12 (P<0.01). miR-744-5p inhibited the growth of MM xenograft tumors in vivo (P<0.001). Conclusion: miR-744-5p inhibits MM cells proliferation, invasion...
confirmed that miR-744-5p expression is significantly increased in PECs from pSS patients, whilst PELI3 was significantly reduced. We validated the miR-744 binding site in the 3’ untranslated region (UTR) of PELI3 and demonstrated that increasing PELI3 levels with a miR-744-5p antagomir in ...
MiR-744-5p inducing cell death by directly targeting HNRNPC and NFIX in ovarian cancer cells 来自 Semantic Scholar 喜欢 0 阅读量: 63 作者:K Michael,S Helga,U Kristian,S Philip,SE Marion,FP Pamela,H René,O Kerstin 摘要: MicroRNAs (miRNAs) are small non-coding RNAs that constitute a ...
０．０５).L I N C ０１１０６靶向负调控m i R Ｇ７４４Ｇ５p ,干扰m i R Ｇ７４４Ｇ５p 可逆转干扰L I N C ０１１０６对M D A ＧM B Ｇ２３１细胞增殖㊁迁移和侵袭的抑制作用.结论㊀L I N C ０１１０６在乳腺癌组织中表达升高,其可能通过靶向负调控m i R Ｇ７４４Ｇ５p 促进乳腺癌细胞...
MiR-490-3p and MiR-744-5p Are Increased in ICU Acquired Weakness (ICUAW) and Regulate Myoblast Differentiation and Proliferation 来自 ResearchGate 喜欢 0 阅读量: 13 作者:J Batt,CE King,CJ Walsh,P Plant,CCD Santos 会议名称: American Thoracic Society 2019 International Conference, May 17-22, ...
744?5p和miR?543表达水平及其对HAND诊断的临床价值.方法 选取HIV?1感染患者76例,分为HAND组(45例)和对照组(31例).采用qRT?PCR法检测患者外周血PBMCs中miR?744?5p和miR?543表达水平;ELISA法检测血清IL?6、IL?10、IL?16、IL?18和TNF?α水平;全自动生化分析仪检测血清HDL、TG、LDL和TC含量.统计学方法分析...