本研究通过评估CRC患者血浆外泌体中miR-590-3p的表达水平及其与患者临床病理特征及预后的关系,证实了miR-590-3p在CRC患者血浆外泌体中呈高表达,且其高表达与多种不良临床病理因素及OS缩短相关;在调整其他混杂因素后,循环血浆外泌体miR-590-3p高...
巨噬细胞外泌体血管内皮细胞血管生成miR-590-3p糖尿病创面是由长期持续性高血糖导致的外周神经病变,血管病变与多致病因素相互作用而引发的创面不良愈合.糖尿病伤口愈合中巨噬细胞极化是一个相对较新的研究领域.糖尿病伤口呈持续性的M1(促炎)巨噬细胞极化,而正常伤口将在创伤后第三天左右显示出向M2(促愈合)巨噬...
99a-3p); miR-590-3p MicroRNA-199a-3p (miR-199a-3p); miR-590-3pMicroRNA-199a-3p (miR-199a-3p); miR-590-3pRodent studies suggest exogenous human miR-590-3p and miR-199a-3p could help promote cardiac repair following MI.Nature Publishing Group USScience-Business eXchange...
㊀㊀摘要:目的㊀观察微小ＲＮＡ￣５９０￣３ｐ(ｍｉＲ￣５９０￣３ｐ)对结直肠癌(ＣＲＣ)细胞顺铂(ＤＤＰ)耐药的影响ꎬ并探讨其可能的机制ꎮ方法㊀在ＣＲＣ细胞系ＳＷ４８０㊁ＳＷ６２０㊁ＨＣＴ１１６中选择ｍｉＲ￣５９０￣３ｐ表达最高的ＳＷ６２０细胞构建ＤＤＰ耐药株(ＤＤＰ/ＳＷ６２０)...
m iR-590 has been found to have anti-tumor effects in many other cancers. However, the role of miR-590-3p in osteosarcoma is poorly understood. In this study, we show that miR-590-3p was significantly decreased both in osteosarcoma tissues and cell lines, suggesting a potential role of ...
CAF-derived exosomes overexpressing miR-590-3p increased cell survival and the ratio of p-PI3K/PI3K and p-AKT/AKT while lowering the expressions of cleaved-PARP, cleaved-caspase 3 and 纬H2AX in cells. Furthermore, in vivo experimental results confirmed that CAF-derived exosomal miR-590-3p ...
目的:应用无血清培养基分离胰腺癌干细胞,检测其miR-590-3p的表达。rn 方法:运用无血清培养基克隆培养ASPC-1,PANC-1细胞,检测其单克隆形成、自我更新及分化、细胞周期、耐药和表面标记物CD24/CD44表达等,验证其肿瘤干细胞特性。qRT-PCR检测miR-590-3p在胰腺癌干细胞中的表达。rn 结果:0.94±0.53%和0.57±0.12%...
In the present study, miR-590-3p, an anti-angiogenic miRNA, was predicted to target VEGFA, a key factor that can be transcriptionally upregulated by HIF1A during ADSC proliferation and tubule formation in response to hypoxic stimulation. Herein, we found that in response to hypoxic stimuli, ...
The main aim of the study is to assess the levels of hsa-miR-590-3p and the role of its downstream target genes in HCC.2. Material and Methods 2.1. In Silico Analysis Several bioinformatics tools were used to predict the potential downstream target genes of hsa-miR-590-3p. For the ...
目的:探究miR-590-3p在甲状腺乳头状癌进展中的作用。方法:利用RT-PCR检测甲状腺乳头状癌患者标本及其细胞系中miR-590-3p的表达。利用CCK-8、EdU、划痕、Transwell实验以及细胞流式技术检测miR-590-3p对细胞相关功能的影响。Western blot检测上皮细胞-间充质转化(epithelial-mesenchymal transiti...