而本研究结果也提示血浆外泌体miR-590-3p高表达的CRC患者可能具有更高的肿瘤复发转移风险及更差的预后,因此在治疗过程中通过检测miR-590-3p也可能有助于预测治疗效果并对预后进行分层,从而为患者制定个体化的治疗方案,最终改善临床结局。 综上所...
㊀㊀摘要:目的㊀观察微小ＲＮＡ￣５９０￣３ｐ(ｍｉＲ￣５９０￣３ｐ)对结直肠癌(ＣＲＣ)细胞顺铂(ＤＤＰ)耐药的影响ꎬ并探讨其可能的机制ꎮ方法㊀在ＣＲＣ细胞系ＳＷ４８０㊁ＳＷ６２０㊁ＨＣＴ１１６中选择ｍｉＲ￣５９０￣３ｐ表达最高的ＳＷ６２０细胞构建ＤＤＰ耐药株(ＤＤＰ/ＳＷ６２０)...
m iR-590 has been found to have anti-tumor effects in many other cancers. However, the role of miR-590-3p in osteosarcoma is poorly understood. In this study, we show that miR-590-3p was significantly decreased both in osteosarcoma tissues and cell lines, suggesting a potential role of ...
m iR-590 has been found to have anti-tumor effects in many other cancers. However, the role of miR-590-3p in osteosarcoma is poorly understood. In this study, we show that miR-590-3p was significantly decreased both in osteosarcoma tissues and cell lines, suggesting a potential role of ...
hsa-miR-590-3p is a good example of one miRNA that is upregulated in a specific cancer and downregulated in another. In this study, we focused on hsa-miR-590-3p’s downstream target genes. We used various bioinformatics analyses to identify the potential downstream target genes of hsa-miR...
目的:应用无血清培养基分离胰腺癌干细胞,检测其miR-590-3p的表达。rn 方法:运用无血清培养基克隆培养ASPC-1,PANC-1细胞,检测其单克隆形成、自我更新及分化、细胞周期、耐药和表面标记物CD24/CD44表达等,验证其肿瘤干细胞特性。qRT-PCR检测miR-590-3p在胰腺癌干细胞中的表达。rn 结果:0.94±0.53%和0.57±0.12%...
MiR-590-3p, Forward: 5′-TAATTTTATGTATAAGCTAGTCCGCG-3′, Reverse: 5′-CTCTACAGCTATATTGCCAGCCAC-3′; MiR-3127-5p, Forward: 5′-ATCAGGGCTTGTGGAATGG-3′, Reverse: 5′-CTCTACAGCTATATTGCCAGCCAC-3′; MiR-548ar-3p, Forward: 5′-TAAAACTGCAGTTATTTTTGCGG-3′, ...
mir-375-3p对hibd大鼠远期行为学的作用：①mir-375-3p在生物体内起着至关重要的调节作用。对于hibd大鼠而言，在远期行为学方面，它可能影响大鼠的运动能力。比如在一些实验中，研究人员设置了特定的运动测试环境，让hibd大鼠在带有障碍物的跑道上奔跑。正常大鼠能够较为敏捷地跨越障碍，保持相对稳定的速度前进。而缺乏...
miR-144-3p可在转录水平抑制mCFs 中Idh2表达，而过表达circ_0120051可增加mCFs中IDH2表达。在mCFs中转染miR-144-3p和Idh2的小干扰RNA （siRNA），可一致性地逆转circ_0120051对纤维化相关基因表达和mCFs迁移的抑制作用。【结论】 Circ_0120051通过特异结合miR-144-3p并增加其靶基因IDH2表达来发挥抑制mCFs纤维化...