MiR-21-5p_通过下调电压门控钾离子通道Kv1.1_表达减轻大鼠三叉神经痛 中南大学学报（医学版）J Cent South Univ (Med Sci)2024, 49(1) http://xbyxb.csu.edu.cn MiR -21-5p 通过下调电压门控钾离子通道Kv1.1表达 减轻大鼠三叉神经痛 周雪雯1, 2，郭刚文1，余珊子3，胡蓉1 [1. 中南大学湘雅三...
M2+miR-21-5p inhibitor 组 相比于M2 macrophage 组,N-cadherin、Snail 和α-SMA蛋白表达水平显著降低,E-cadherin 蛋白表达水平显著升高。说明发生 M2 型极化的巨噬细胞可促进食管癌细胞的 EMT 过 程,而抑制M2 型巨噬细胞中miR-21-5p 的表达,则与之相反。 四、外泌体miR-21-5p 促巨噬细胞极化对食管癌...
In this study, we aimed to investigate the regulatory role of the miR-21-5p/RhoB axis in EMT and related in vitro functional characteristics such as migration, invasion, cisplatin resistance, and the formation of tumor spheroids.#A549 cells were transfected with the miR-21-5p inhibitor, RhoB ...
(BPD + Exos-miR-21 group), and hyperoxia combined with exosome miR-21 inhibitor treatment group (BPD + Exos-AV-miR-21 group). Neonatal SD rats will be exposed to 85% oxygen to establish a BPD model. Following 14 days of high oxygen treatment, the expression levels of miR-21 in lung...
A computational analysis revealed the presence of a putative binding site for miR-21-5p within the 3’UTR of YAP1, as depicted in Fig.5A. Intriguingly, the introduction of miR-21-5p inhibitor led to a discernible increase in luciferase activity when the YAP1-3’UTR (YAP1-Wt) was present...
miRi: miR-21-5p inhibitor Full size image LGG-EVs activate the functions of endothelial cells and keratinocytes via transferring miR-21-5p To investigate if the pro-healing effects of LGG-EVs were mediated by miR-21-5p, we transfected a miRi that specifically reduces miR-21-5p before LGG-...
4b, more cells were adhered to HMrSV5 cells in mimics group compared to negative control group, and miR-21-5p inhibitor significantly decreased the numbers of the adhered cells. For invasion assays, overexpression of miR-21-5p markedly increased invasion of HMrSV5; in contrast, HMrSV5 cells...
Up-regulation of microRNA-126 may contribute to pathogenesis of ulcerative colitis via regulating NF-kappaB inhibitor IκBα[J]. PLoS One, 2012,7(12):e52782. DOI: 10.1371/journal.pone.0052782 返回引文位置Google Scholar 百度学术 万方数据 [4] Takagi T , Naito Y , Mizushima K ,et al. ...
and primers of mouse KRIT1 3′UTR were designed using Primer Premier 5.0. The KRIT1 3′UTR plasmids were co-transfected with mimics or inhibitor of miR-21-5p into the cells using Lipofectamine 3000 (Invitrogen, Carlsbad, CA, USA). After 48 h, luciferase activity was measured by the Du...
i-miR or i-NC, MSCs were transfected with miR-21-5p inhibitor or microRNA inhibitor negative control before hypoxia challenge and EV isolation. Vehicle, MSCs were treated with transfection reagent without the vector. MSCs cultured in normoxic condition (Norm.) were used as negative control. b,...