本发明提供了一种肿瘤曲妥珠单抗靶向antimiR21纳米粒子,为抗肿瘤曲妥珠单抗靶向载药高分子负载antimiR21的纳米粒子,所述抗肿瘤曲妥珠单抗靶向载药高分子的结构式如式(I)所示.本发明还提供了上述肿瘤曲妥珠单抗靶向antimiR21纳米粒子的制备方法.该肿瘤曲妥珠单抗靶向antimiR21纳米粒子靶向性好,毒副作用小,其制备方法工艺...
Trimannose-coupled antimiR-21 for macrophage-targeted inhalation treatment of acute inflammatory lung damage Christina Beck, Deepak Ramanujam, Paula Vaccarello, Florenc Widenmeyer, Martin Feuerherd, Cho-Chin Cheng, Anton Bomhard, Tatiana Abikeeva, Julia Schädler, Jan-Peter Sperhake, ...
1. AntimiR-21局部注射抑制miR-21的表达 作者首先确定短暂栓塞下miR-21的表达情况,发现短暂阻断左前降支(60分钟)后,左心室心肌的远区和边缘区的miR-21表达逐渐上调(图1A)。接着进行缺血/再灌注(I/R),5天内不进行治疗以形成疤痕,分别在I/R后第5天和第19天进行将LNA修饰的antimiR-21注入冠状动脉(图1B),...
Effect of 2鈥 -sugar and phosphate backbone modifications on hybridization and anti-miR-21 activity of ASOsScott, DavisBridget, LolloSusan, FreierChristine, Esau
We hypothesized that MSC-shed exosomes will serve as carriers for anti-miR-21 and these MSC can be utilized to deliver miRzip-21 to the tumors in vivo (Fig. 3A). To determine the exosome enrichment of anti-miR-21 from transduced MSCs, exosomes were harvested from MSCs transduced with LV...
Anti-miR-214 or pre-miR-214 was used to down-regulate or up-regulated miR-214 expression. The results showed that NCTD drastically impaired tumor growth in hepatoma-bearing mice, correlating with increased anti-tumor activity of TAMs. Moreover, NCTD stimulation led to an alteration of HCC ...
Results There was a significant correlation of miR-10b expression level with cell motility and invasiveness. Low-level expression of miR-10b was observed in HepG2 cells, which exhibited weak motility and invasiveness; whereas high-level expression of miR-10b was observed in MHCC97H cells, which...
Anti-miR-21 oligonucleotide sensitizes leukemic K562 cells to arsenic trioxide by inducing apoptosis. Li Y,Zhu X,Gu J,Dong D, et al. Cancer Science . 2010Li Y, Zhu X, Gu J, Dong D, Yao J, Lin C, et al. Anti-miR-21 oligonucleo tide sensitizes leukemic K562 cells to ...
Anti-miR-21 oligonucleotide enhances chemosensitivity of leukemic HL60 cells to arabinosylcytosine by inducing apoptosis. Hematology. 2010; 14 :215–221. [ PubMed ]Li Y,Zhu X,Gu J. Anti-miR-21 oligonucleotide enhances chemosensitivity of leukemic HL60 cells to arabinosylcytosine by inducing ...
Abstract A174: Antitumor activity of lipid nanoparticle-delivered anti-miR-21doi:10.1158/1535-7163.TARG-23-A174Background: MicroRNAs (miRNAs) are small non-coding RNA molecules that play crucial roles in various biological processes, such as growth, development, aging, and apoptosis. Several ...