EIF4E3蛋白呈低表达;miR-208a-3p靶向负调控EIF4E3的表达;下调miR-208a-3p或过表达EIF4E3可增强萝卜硫素对HepG2细胞增殖、侵袭及迁移的抑制作用,而过表达miR-208a-3p或沉默EIF4E3则呈相反趋势;同时过表达miR-208a-3p和EIF4E3不会影响萝卜硫素对HepG2细胞增殖、侵袭...
下调miR-208a-3p或过表达EIF4E3可增强萝卜硫素对HepG2细胞增殖,侵袭及迁移的抑制作用,而过表达miR-208a-3p或沉默EIF4E3则呈相反趋势;同时过表达miR-208a-3p和EIF4E3不会影响萝卜硫素对HepG2细胞增殖,侵袭及迁移的抑制作用.结论 萝卜硫素可能通过下调miR-208a-3p进而上调EIF4E3的表达来抑制HepG2细胞增殖,...
EIF4E3蛋白呈低表达;miR-208a-3p靶向负调控EIF4E3的表达;下调miR-208a-3p或过表达EIF4E3可增强萝卜硫素对HepG2细胞增殖、侵袭及迁移的抑制作用,而过表达miR-208a-3p或沉默EIF4E3则呈相反趋势;同时过表达miR-208a-3p和EIF4E3不会影响萝卜硫素对HepG2细胞增殖、侵袭...
miR-208a-3p overexpression attenuated myocardial I/R injury. This study aims to investigate the role and mechanism of miR-208a-3p in I/R-induced AKI. Methods: AKI models were established using hypoxia/reoxygenation (H/R)-exposed tubule epithelial cell HK-2 and I/R-induced mice. The ...
Silencing miR-208a-3p significantly alleviated macrophage inflammation and osteoblast activation, which was reversed by the knockdown of STC1. Conclusion: Serum miR-208a-3p served as a diagnostic biomarker for OP and a risk factor for fracture in post-menopausal women. miR-208a-3p regulated ...
miR-208a-3p右心房心肌组织心房重构目的:本研究通过实时荧光定量聚合酶链反应(RT-q PCR)法检测风湿性心脏瓣膜病,先天性心脏病等心血管疾病患者右心房心肌组织中miR-133a-3p,miR-208a-3p相对表达量,并通过Masson染色观察其纤维化程度,免疫组化检测其I型胶原蛋白量的表达;旨在探讨micro RNAs在心肌重构发生机制中的...
Moreover, BMSCs-Exo-rno-miR-208a-3p promoted cyclin D1, CDK6, and Bcl-2 and inhibited Bax expression in a cell model of SCI. In conclusion, BMSCs-Exo-carried rno-miR-208a-3p significantly protects rats from SCI via regulating the Cdkn1a pathway....
Moreover, A. muciniphila pretreatment significantly modulated the gut microbiota in hypoxia-induced PH mice. miRNA sequencing analysis reveals that miR-208a-3p, a commensal gut bacteria-regulated miRNA, was markedly downregulated in lung tissues exposed to hypoxia, which was restored by A. mucini...
miR-208a-3ppreclinicaltime-dependent profilingDrug-induced cardiac injury (DICI) detection remains a major safety issue in drug development. While circulating microRNAs (miRs) have emerged as promising translational biomarkers, novel early detection biomarkers of cardiotoxicity are needed. This work aims ...
miR-208a-3pAutophagyPDCD4ATG5Pathological cardiac hypertrophy is the main determinant of the development of heart failure, for which there is often no effective therapy. The dysregulation of autophagy is implicated in hypertrophy, but the mechanism linking these processes is unclear. In this study, ...