此外,rescue实验表明hsa_circ_0043280过表达可以恢复miR-203a-3p降低的PAQR3表达水平,并且减弱miR-203a-3p引起的细胞增殖和迁移能力的增强。这表明hsa_circ_0043280可能作为miRNA海绵介导宫颈癌的肿瘤表型。 图3 Hsa_circ_0043280吸附miR...
结论miR-203a-3p可以通过靶向调控VEGF-C表达抑制卵巢癌细胞增殖、侵袭和迁移，其机制可能与抑制增殖相关蛋白和调控上皮间质化过程相关。[关键词]卵巢癌；miR-203a-3p;血管内皮生长因子C;细胞侵袭；细胞迁移 Doi： 10. 3969/j. issn. 1673-5293. 2022. 01. 012 [中图分类号]R737. 31 [文献标识码]A [文章...
miR-203a-3p inhibitor转染组低于对照转染组中IGFBP5的表达量,高于miR-203a-3p mimic转染组中IGFBP5基因的表达量,但均并未达到显著水平;转染miR-139-5p mimic的细胞中,IGFBP5基因的表达量显著低于对照转染组,miR-139-5p inhibitor转染组低于对照转染组中IGFBP5的表达量,高于miR-139-5p mimic 转染组中IGFBP5基因...
miR-203a-3p、SOCS1、SOCS3诊断子宫内膜异位症不孕症的曲线下面积(AUC)分别为0.866、0.818、0.806,三者联合诊断的AUC为0.929,特异性为90.8%,敏感度为84.2%。异位组中,与妊娠结局良好组相比,不良组患者血清miR-203a-3p水平较高,SOCS1、SOCS3水平较低(均P<0.05)。结论:子宫内膜异位症不孕患者血清miR-203a-3p水平...
(图1A和图1B)显示,与control组和miR-NC组比较,miR-203a-3p组HepG2细胞中miR-203a-3p表达量升高(t=31.572,30.560;均P<0.001);与miR-NC组比较,miR-203a-3p组HepG2细胞中LASP1 mRNA表达量降低(t=28.438,P<0.001);与miR-2...
结果与Control组比较,Model组大鼠肺损伤及肺纤维化程度较为严重,肺组织W/D值及Hyp含量增加(P<0.05),BALF中IL-1β、IL-6和TNF-α水平升高(P<0.05),肺组织中miR-203a-3p表达水平降低(P<0.05),而Fstl1 mRNA和蛋白表达水平升高(P<0.05)。与Model组比较,agomir组大鼠肺损伤及纤维化得到改善,肺组织W/D值及...
货号:dre-miR-203a-3p 原价:￥4030 现价:￥3098.38节省:￥932 规格:1 kits 说明:dre-miR-203a-3p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录...
In summary, this study highlights an onco-miRNA role for miR-203a-3p by regulating PDE4D in CRC and suggests that miR-203a-3p may be a novel molecular therapeutic target for CRC. 展开 关键词: Colorectal cancer, micro-RNA, miR-203a-3p, PDE4D ...
通过RT-qPCR实验检测miR-203a-3p的表达情况.5,脂质体转染miR-203a-3p的mimic,m-NC,inhibitor,i-NC至BMSCs,诱导7d,采用免疫荧光实验观察与早期成软骨细胞分化相关蛋白Sox9,Coll2a的荧光强弱,通过Western Blot实验检测Sox9,Coll2a蛋白的表达水平.6,生物信息学网站预测miR-203a-3p的靶基因,通过免疫荧光,Western Blot...
MicroRNAs (miRNAs) have been explored in many critical cellular processes, including proliferation and apoptosis. The purpose of this study was to detect the biological function and regulation of miR-99b-5p and miR-203a-3p in gastric cancer (GC). Here, we demonstrated that miR-99b-5p/203a-...