MAPK信号通路,急性髓系白血病和慢性粒细胞白血病等信号通路.结论:(一)上调的miR-193b-3p通过靶向LACM1基因,在非M3中发挥抑癌因子作用.(二)(1)下调的miR-196b-5p通过靶向PTPRG基因和RAS通路可促进AML的发生;(2)通过靶向基因PBX3和激活MAPK信号途径诱导癌基因发挥作用;(3)通过靶向基因PBX和HOX的相互作用发挥致癌...
本研究在体外水平探讨了miR-196b-5p在成脂分化、脂质合成和脂质分解中的功能及其作用机制。方法1.在骨髓基质细胞系ST2及间充质干细胞系C3H10T1/2中,运用实时定量PCR(qRT-PCR)技术检测miR-196b-5p在转染miR-196b-5p mimics后的变化。在两个细胞系中升高或降低miR-196b-5p水平,成脂诱导分化后用油红O染色、...
MiR-107 was upregulated in OSC (p≤ 0.005) and miR-196b-5p was upregulated in SCCC (p≤ 0.05) (Supplementary Figure S3). One other miRNA, miR-493-3p, showed a trend for statistical significance in the discovery cohort, and was found significantly differentially expressed in the validation...
货号:ssc-miR-196b-5p 原价:￥4030 现价:￥3098.38节省:￥931.62 规格:1 kits 说明:ssc-miR-196b-5p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制...
EVs rich in miR-196b-5p mediate the crosstalk between PTECs and fibroblast during the development of renal fibrosis, which might be associated with STAT3/SOCO2 signaling pathway. 展开 关键词: tubulointerstitial changes fibroblast fibrosis DOI: 10.1136/bmjdrc-2019-001101 ...
In pull-down assays, there was a 3.4- and 5.2-fold increase in miR-196a-5p (P = 0.054) and miR-196b-5p (P = 0.035), respectively, using the UGT2A1 3'-UTR biotinylated mRNA probe as compared with the β-actin coding region control mRNA probe. UGT2A1 mRNA was reduced by 25% ...
Circ_0078607, miR-196b-5p, and growth arrest-specific 7 (GAS7) levels were assessed by qPCR. Circ_0078607 stability was assessed by ribonuclease R digestion and actinomycin D treatment. Cell viability of various conic of DDP treatment was measured by CCK-8. The cell proliferation was ...
miR-196b-5p Affects Macrophage Polarization and Inflammation in Endometriosisdoi:10.22034/iji.2024.102744.2794Zhe XueYuyan GuoFangyun WangQinping YangQiuhong ChenTingting LinShunhe LinIranian Journal of Immunology
Moreover, miR-196b-5p indirectly negatively regulates METTL3 in SCAPs. Then, METTL3 was found to strengthen the ALP activity assay, mineralization, and expressions of osteo/dentinogenic differentiation markers. Taken together, our findings highlight the critical roles of the METTL3-miR-196b-5p ...
miR-196b-5p过表达组CT26.WT细胞中MDR,MRP,LRP,磷酸化PI3K(phospho-PI3K,p-PI3K)及p-AKT蛋白的表达水平均明显低于Exosomes组(未转入mimic或inhibitor的BMSCs分泌的外泌体)(P值均<0.01),而miR-196b-5p低表达组中各耐药相关蛋白的表达水平均明显高于Exosomes组(P值均<0.01).结论:携带有高水平miR-196b-5p的...