EVs rich in miR-196b-5p mediate the crosstalk between PTECs and fibroblast during the development of renal fibrosis, which might be associated with STAT3/SOCO2 signaling pathway.doi:10.1136/bmjdrc-2019-001101Renzhi HuXuan LiChuan PengRuifei Gao...
本研究在体外水平探讨了miR-196b-5p在成脂分化、脂质合成和脂质分解中的功能及其作用机制。方法1.在骨髓基质细胞系ST2及间充质干细胞系C3H10T1/2中,运用实时定量PCR(qRT-PCR)技术检测miR-196b-5p在转染miR-196b-5p mimics后的变化。在两个细胞系中升高或降低miR-196b-5p水平,成脂诱导分化后用油红O染色、...
EVs rich in miR-196b-5p mediate the crosstalk between PTECs and fibroblast during the development of renal fibrosis, which might be associated with STAT3/SOCO2 signaling pathway. 展开 关键词: tubulointerstitial changes fibroblast fibrosis DOI: 10.1136/bmjdrc-2019-001101 ...
货号:ssc-miR-196b-5p 原价:￥4030 现价:￥3098.38节省:￥932 规格:1 kits 说明:ssc-miR-196b-5p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转...
QKI-5 bound to miR-196b-5p and influenced its stability, resulting in up-regulated miR-196b-5p expression in NSCLC. Further analysis showed that hypomethylation in the promoter region enhanced miR-196b-5p expression in NSCLC. Our findings indicate that QKI-5 may exhibit novel anticancer ...
In pull-down assays, there was a 3.4- and 5.2-fold increase in miR-196a-5p (P = 0.054) and miR-196b-5p (P = 0.035), respectively, using the UGT2A1 3'-UTR biotinylated mRNA probe as compared with the β-actin coding region control mRNA probe. UGT2A1 mRNA was reduced by 25% ...
After up-regulating the expression of miR-196b-5p, proliferation of MDS-L cells was up-regulated, whereas apoptosis was down-regulated (P < 0.05). In contrast, down-regulation of miR-196b-5p expression decreased cell proliferation and increased apoptosis (P < 0.05). We concluded that over-...
mirhepatocellularcarcinomahsaaxisbcb RP5-1120P11.3promoteshepatocellularcarcinomadevelopmentvia hsa-miR-196b-5p/WIPF2axis HongjunZhai,XinwuZhang,ShuoChen,MengFan,ShuangyuMa,XiaoliSun * GeneralSurgeryDepartment,TheSecondAffiliatedHospitalofXi’anJiaotong University,XinwuRoad157,XinchengDistrict,Xi’an,Shaanxi Prov...
miR‐196‐5pWharton's jelly umbilical cord stem cellsHuman umbilical cord mesenchymal stem cells (HUCMSCs) can be obtained from different parts of the umbilical cord, including Wharton's jelly. Transplantation of Wharton's jelly umbilical cord stem cells (WJCMSCs) is a promising strategy for ...
Conclusion: MiR-196b-5p regulates cell proliferation in drug-resistant HCC cell lines via activation of the NFkB/ABCB1 signaling pathway.doi:10.4314/tjpr.v19i1.6Bangming PuYong CaoYan LiLi TangJiyi XiaBo LiAfrican Journals Online (AJOL)Tropical Journal of Pharmaceutical Research...