这些实验都表明circTLK1作为miR-136-5p的海绵。 5.miR-136-5p通过靶向CBX4促进肾癌进展 为了确定miR-136-5p的潜在基因,我们利用TargetScan、miRDB、Starbase和miRTarBase数据库进行了生物信息学分析,选择CBX4、GNAS、LUZP6、MSL2、MTMR4和SOCS7作为miR136-5...
这些实验都表明circTLK1作为miR-136-5p的海绵。 5.miR-136-5p通过靶向CBX4促进肾癌进展 为了确定miR-136-5p的潜在基因,我们利用TargetScan、miRDB、Starbase和miRTarBase数据库进行了生物信息学分析,选择CBX4、GNAS、LUZP6、MSL2、MTMR4和SOCS7作为miR136-5p的潜在靶点(图5a)。进一步的综合转录分析表明miR-136-5p表...
miR-136-5pTXNIPsepsisACUTE KIDNEY INJURYTHIOREDOXIN-INTERACTING PROTEINCIRCULAR RNABIOMARKERSEPSISEXOSOMESBackground: The implication of circular RNAs (circRNAs) in sepsis-related complications arouses much attention, which provides additional treatment options for sepsis-related complications. The purpose of ...
chi-miR-136-5p qPCR试剂盒 分类:microRNA qPCR Kits 品牌:BioTNT 货号:chi-miR-136-5p 原价:￥4030 现价:￥3098.38 节省:￥932 规格:1 kits 说明:chi-miR-136-5p 特异性茎环引物试剂盒 ￥615产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方...
In conclusion, we intended to reveal that TJ-M2010-5 up-regulated miR-136-5p levels, changing the imbalance in anti-inflammatory regulation induced by the MyD88 promoter methylation and alleviating inflammatory responses by involving the PI3K/AKT3 pathway....
To identify potential targets of miR-136-5p, we compared its sequence to the mouse genome database. The results showed that the 3′ UTR region of AKT3 contained potential binding sites for the miR-136-5p sequence (Figure5A). Thus, we transfected miR‐136-5p mimics into HEK 293 T cells...
In addition, PlncRNA-1 modulated the expression of smad3 and has-miR-136-5p (miR-136). Conversely, miR-136 regulated the expression of PlncRNA-1 and smad3. PlncRNA-1 mimics competitive endogenous RNA (ceRNA) in its regulation of smad3 expression by binding miR-136. Rescue analysis ...
(ROCK1) via acting as a sponge of microRNA (miR)-136–5p. SNHG14 promoted neurological impairment and inflammatory response through elevating the expression of ROCK1 while decreasing miR-136–5p level in OGD/R induced damage. Collectively, we illustrated that SNHG14 could be a novel ...
miR-136-5p通过靶向IKKβ调控NF-κB信号通路影响脊髓损伤炎症因子表达的机制研究 【目的】脊髓损伤(Spinal cord injury,SCI)是一种目前世界范围内发病率高的难治性损伤性疾病,目前尚无特别有效的治愈手段,因此迫切需要对SCI的发病机制和新疗法进行研究.miR-136-5p和IKKβ/NF-κB作为基因表达的调控因子,在脊髓损伤发...
由于旁分泌信号在此过程中的重要性,因此从DP细胞培养物中分离出了分泌组和外泌体,并研究了它们的治疗效果。证明了miR-218-5p在DP球体来源的外泌体中明显上调。Western印迹和免疫荧光成像被用来证明DP球体衍生的外泌体上调了β-caten...