RNA-seq显示50个差异表达的外泌体miRNAs在登革热感染期间明显异常。经过广泛的验证，miR-96-5P被发现随着病情的发展而显著上调，而miR-146A-5P则显著下调。有趣的是，miR-96-5p和miR-146a-5p的表达水平与患者血小板水平呈强正相关。进一步的研究表明，miR-146a-5p调控了大部分参与免疫应答的蛋白的表达。这些结果表...
miR-146-5p mimics were used to upregulate miR-146-5p with NC mimics as negative controls. Coding regions of TRAF6 were subcloned into the pcDNA3.1 vector to elevate TRAF6 expression with empty pcDNA3.1 as a negative control. All plasmids or oligonucleotides mentioned above were purchased from ...
肾纤维化慢性肾疾病目的明确miR-146b-5p在小鼠肾纤维化模型中的表达情况,并探讨体内敲低miR-146b-5p对小鼠肾损伤及纤维化的影响.方法将24只8周龄C57BL/6雄性小鼠随机分为假手术组(sham),UUO模型组(UUO),UUO+肾miR-146b-5p电转敲低组(UUO-KD),每组8只.Sham组仅切开皮肤,暴露且游离右侧肾输尿管,不做...
[目的]miR-146b-5p是胶质瘤的抑癌miRNA (Tumour suppressing miRNA, TS-miRNA).浸润性生长是胶质瘤的突出特征,也是导致其手术不易全切,术后复发率高及预后不良的主要原因.已知基质金属蛋白酶16(Martrix metalloproteinase16, MMP16)过表达与多种颅外恶性肿瘤的浸润性生长密切相关.生物信息学预测提示MMP16可能是mi...
hsa-mir-146b-5p RT-PCR反应引物 英文名称: hsa-mir-146b-5p RT-PCR Primer Set 品牌: Abbexa 货号: abx096876 规格: 1 nmol 价格: $246.5 产品说明书下载: 产品预定 >> 产品预定,提交订单信息之后,我们会第一时间与您取得联系 试剂和工具 试剂...
gga-miR-146c-5p qPCR试剂盒 分类:microRNA qPCR Kits 品牌:BioTNT 货号:gga-miR-146c-5p 原价:￥4030 现价:￥3098.38 节省:￥932 规格:1 kits 说明:gga-miR-146c-5p 特异性茎环引物试剂盒 ￥615产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对...
摘要 目的探究miR-146b-5p促进食管鳞状细胞癌恶性表型的分子机制。方法选取2020年10月-2021年12月在四川省西南医科大学附属医院行食管癌根治术治疗的38名食管鳞状细胞癌患者的癌组织和癌旁正常组织(NAT)样本,...展开更多 Objective To explore the molecular mechanism by which miR-146b-5p promoted the malignant...
甲状腺癌是一类严重危害人类身体健康的常见病和多发病,其发生,发展与多种基因的异常密切相关.miR-146b-5p是新发现的一类机体内源性表达的小分子单链RNA家族成员,通过与靶基因的相互作用来参与机体细胞的功能调控.研究发现miR-146b-5p在包括甲状腺癌在内的多种肿瘤中异常表达,与肿瘤的发生,发展,转移,浸润关系密切....
Micro-RNA (miR)-146b-5p is overexpressed in papillary thyroid carcinoma (PTC) and associated with extrathyroidal invasion and advanced tumor stage. In the present study, we showed that miR-146b-5p is upregulated in PTC with lymph node metastasis.A computational search and luciferase assay iden...
Downstream miR-146b-5p targets modulating VSMC phenotypes will be further identified. Our study will help to understand the role of VSMCs in the pathology of vascular diseases. 展开 关键词: miR-146b-5p, vascular smooth muscle cells, migration, proliferation ...