Furthermore, we found that miR-135b-5p is also up-regulated in gastric tumors from the trefoil factor 1-knockout mouse model. Infection with H. pylori induced the expression of miR-135b-5p in the in vitro and in vivo models. miR-135b-5p induction was mediated by NF-魏B. Treatment ...
PGAM1 是 miR-135b-5p 的靶基因:通过生物信息学预测和多种实验验证,包括双荧光素酶报告基因实验、RIP 实验、Western blotting 和 qRT-PCR 等,证实 PGAM1 是 miR-135b-5p 的直接靶基因,miR-135b-5p 可抑制 PGAM1 的表达。 SPINT1-AS1 通过调节 miR-135b-5p/PGAM1 轴促进 OS 进展和增强有氧糖酵解:...
赵格, 黎昌学, 郭超, 朱慧 Expression and relevant bioinformatics analysis of miR-135b-5p in oral squamous cell carcinoma ZHAO Ge, LI Changxue, GUO Chao, ZHU Hui 表3miR-135b-5p靶基因KEGG信号通路显著性富集分析结果 Table 3Significantly enriched KEGG pathways of target genes of miR-135b-5p ...
Jinyou Wang, Ning Zhang, Yan Wang, Fanghong Chen, Lei Wang, Kailun Wang, Xiao Yao & Xiaohui Pan. (2025) LncRNA SPINT1-AS1 enhances the Warburg effect and promotes the progression of osteosarcoma via the miR-135b-5p/PGAM1 axis.Cancer Cell International25:1. ...
25, NO. 1, 2373497 https://doi.org/10.1080/15384047.2024.2373497 RESEARCH PAPER MiR-135b-5p promotes cetuximab resistance in colorectal cancer by regulating FOXN3 Chun Peng*, Xiaoqing Li*, Yuhui Yao, Yu Nie, Lingyao Fan, and Chuandong Zhu Department of Oncology, The Second Hospital of ...
设计miR-135b-5p和miR-499a-3p的特异性引物,通过Real-Time PCR检测两种miRNA的表达.3,荧光素酶报告载体的构建:利用PCR技术扩增包含结合位点的MEF2C3'UTR区域,并将该区域连入荧光素酶报告载体,利用双荧光素酶报告试剂盒检测荧光强度的变化.4,Western blot:在HEK293和HUVEC细胞中分别转染miR-135b-5p和miR-499a...
dre-miR-135b-5p qPCR试剂盒 分类:microRNA qPCR Kits 品牌:BioTNT 货号:dre-miR-135b-5p 原价:￥4030 现价:￥3098.38 节省:￥932 规格:1 kits 说明:dre-miR-135b-5p 特异性茎环引物试剂盒 ￥615产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对...
血清miR-135b-5p水平对于RCC筛查的ROC曲线下面积(AUC^(ROC))为0.711(95%CI:0.619~0.802)。ACHN和Caki-1细胞中miR-135b-5p水平较正常HK-2细胞中的表达倍数显著明显升高(分别升高了7.821倍和1.919倍。P值分别为0.000 3和0.000 1);同时,ACHN和Caki-1 EVs中miR-135b-5p水平较HK-2 EVs中的表达倍数亦显著...
miR-135b-5p,miR-126-3p水平分别为0.49±0.11,0.53±0.12,轻度组分别为0.79±0.15,0.71±0.14,两组比较差异均有统计学意义(均P<0.05);妊娠结局不良组血清miR-135b-5p,miR-126-3p水平分别为0.53±0.12,0.52±0.11,良好组分别为0.81±0.18,0.75±0.15,两组比较差异均有统计学意义(均P<0.05).miR-135b-5p与...
vivofunctional assessment. KLF4 was a downstream target of miR-135b-5p. KLF4 could regulate GPRC5A level. MiR-135b-5p was notablyincreased in cancer cells, and overexpressing KLF4 functioned a tumor repressive role, which could be restored by miR-135b-5p.Besides, cell malignant phenotypes ...