miR-135b是一种在结肠癌细胞中合成量较高的RNA。科研人员研究了miR-135b含量对结肠癌细胞的细胞凋亡和细胞周期的影响,结果如表1所示。表1miR-135b对结肠癌细胞细...
MicroRNA-135b (miR-135b)Studies in human samples and mice suggest inhibiting miR-135b could help treat colon cancer.Science-Business eXchangedoi:10.1038/scibx.2014.555None
In this study, we found that the expression of miR-135b was upregulated in HCC tissues and cell lines. Additionally, expression of miR-135b positively correlated with HCC stages and negatively correlated with the survival of HCC patients, suggesting an oncogenic role of miR-135b in HCC. We...
Moreover, miR-135b triggers histopatho- logical abnormalities via an enhanced degradation of the extracellular matrix by the increased matrix metalloproteinase 2 (MMP2) through the direct downregulation of thrombo- spondin 2 (THBS2). Finally, we show statistical significance and clinical relevance of...
pEGP-mmu-mir-135b Expression Vector 英文名称: miRNASelect? pEGP-mmu-mir-135b Expression Vector 总访问: 140 国产/进口: 进口 半年访问: 12 产地/品牌: 美国Cell Biolabs 产品类别: 细胞生物学试剂 规格: MMU-MIR-135B 最后更新: 2024-12-5 货号: CAS 号: 参考报价: 询价 立即询价 电话咨询 ...
关键词:乳腺癌;㊀化疗;㊀耐药性;㊀m i RＧ６７１Ｇ３p;㊀m i RＧ１３５b D O I:１０．３９６９/j．i s s n．１６７３Ｇ４１３０．２０２２．１４．０２１中图法分类号:R７３７．９ 文章编号:１６７３Ｇ４１３０(２０２２)１４Ｇ１７６６Ｇ０６文献标志码:A R e l a t i o n s h i p ...
目的探讨miR-135b对肝癌细胞浸润转移的影响及其分子机制.方法分别在肝癌细胞系中过表达和下调miR-135b,通过Transwell~(TM)实验检测肿瘤细胞迁移和侵袭能力,利用肝癌移植瘤模型检测肝癌细胞的体内增殖能力和成瘤能力;采用Western blot法结合双荧光素酶基因报告系统预测miR-135b的下...
vivofunctional assessment. KLF4 was a downstream target of miR-135b-5p. KLF4 could regulate GPRC5A level. MiR-135b-5p was notablyincreased in cancer cells, and overexpressing KLF4 functioned a tumor repressive role, which could be restored by miR-135b-5p.Besides, cell malignant phenotypes ...
Here, we show that the molecular clockwork within malignant human pancreatic epithelium is disrupted and that this disruption is mediated by miR-135b-induced BMAL1 repression. miR-135b directly targets the BMAL1 3′-UTR and thereby disturbs the pancreatic oscillator, and the downregulation of miR...
目的 探究miR-135b靶向糖原合成酶激酶3B(glycogen synthase kinase 3B,GSK3B)对地塞米松诱导的成骨细胞(MC3T3-...