关联检验中的reference与risk/effect allele在关联检测中，reference allele（non-risk或non-effect）是效应估计的基准，与参考基因组中的ref/alt概念分离。早期研究中，minor allele常被作为reference allele，但现在，为了消除混淆，研究者倾向于保持与reference genome的统一。risk allele则是与疾病关联的allel...
在这里的概念再次改变,同样的reference allele,在与 risk/effect allele并列时,则指的是GWAS关联检测中的reference allele (non-risk 或者 non-effect),也就是效应量beta(或odds ratio)估计时的参考,概念上与上述ref与alt的组合无关,但为了保持统一性,近年来研究中关联检验的reference 也会与 reference genome保持一...
在这里的概念再次改变,同样的reference allele,在与 risk/effect allele并列时,则指的是GWAS关联检测中的reference allele (non-risk 或者 non-effect),也就是效应量beta(或odds ratio)估计时的参考,概念上与上述参考基因组的ref与alt的组合无关,但为了保持统一性,近年来研究中关联检验的reference 也会与 reference...
Effect of minor allele frequency on the number of single nucleotide polymorphisms needed for accurate parentage assignment: A methodology illustrated using Atlantic salmonanimal breedingaquacultureminor allele frequencyparentageSalmo salarsingle nucleotide polymorphisms...
Within a population, two or more base-pair possibilities can exist for a givenSNP, known as alleles. The frequency of an SNP is determined by the frequency of the less common allele, known as theminor allele frequency.The frequency of an allele within a population and the risk for complex...
Besides, correcting the sequence-context effect substantially increases the detection accuracy of the single-locus methods. The threshold of base QV also has a minor impact on the accuracy. A non-zero threshold increases the accuracy on the Bordetella spp. data (Fig. 4a), but decreases the ...
While it is well known that epicardial adipose tissue has inflammatory-metabolic effect via "inside out" pathway, its local mechanical effect and accumulation of intramyocardial fat are less investigated.关键词: obesity right ventricle diastolic dysfunction ...
英文：minor allele frequency 中文：次要等位基因频率 可能您的英文不是很完整，导致翻译的结果不是很流畅 也许是翻译水平有限，请见谅 很高兴为您解答 您的采纳是我答题的动力 祝你生活愉快，学习进步 如果你对这个答案有什么疑问，请追问 手机用户点击右上角的【满意】如果满意记得采纳哦·~~...
A single gene controlling the response to Ea-1 antigens, which segregates when strains YBR and B10.D2 are crossed, has been shown not to be an allele of theIr-2 locus. A new phenomenon has also been observed in the control of anti-Ea-1 antibody production in that the mating of two...
Most eukaryotes harbor two distinct pre-mRNA splicing machineries: the major spliceosome, which removes >99% of introns, and the minor spliceosome, which removes rare, evolutionarily conserved introns. Although hypothesized to serve important regulato