在这里的概念再次改变,同样的reference allele,在与 risk/effect allele并列时,则指的是GWAS关联检测中的reference allele (non-risk 或者 non-effect),也就是效应量beta(或odds ratio)估计时的参考,概念上与上述参考基因组的ref与alt的组合无关,但为了保持统一性,近年来研究中关联检验的reference 也会与 reference...
关联检验中的reference与risk/effect allele在关联检测中，reference allele（non-risk或non-effect）是效应估计的基准，与参考基因组中的ref/alt概念分离。早期研究中，minor allele常被作为reference allele，但现在，为了消除混淆，研究者倾向于保持与reference genome的统一。risk allele则是与疾病关联的allel...
在这里的概念再次改变,同样的reference allele,在与 risk/effect allele并列时,则指的是GWAS关联检测中的reference allele (non-risk 或者 non-effect),也就是效应量beta(或odds ratio)估计时的参考,概念上与上述ref与alt的组合无关,但为了保持统一性,近年来研究中关联检验的reference 也会与 reference genome保持一...
Effect of minor allele frequency on the number of single nucleotide polymorphisms needed for accurate parentage assignment: A methodology illustrated using Atlantic salmonanimal breedingaquacultureminor allele frequencyparentageSalmo salarsingle nucleotide polymorphisms...
We also found that even at the same effect size, the minor allele is more likely to be identified as an associated allele, because P-values are lower in association studies when the minor rather than the major allele is the risk allele. Furthermore, we found that diseases with different ...
Within a population, two or more base-pair possibilities can exist for a givenSNP, known as alleles. The frequency of an SNP is determined by the frequency of the less common allele, known as theminor allele frequency.The frequency of an allele within a population and the risk for complex...
Results: After adjustment for the confounding variables age and CD4 count, the CYP2B6 516 T-allele was protective against late HIV virologic breakthrough, adjusted OR 0.70; 95% CI: 0.50 to 0.97. Conclusion: The CYP2B6 516 T-allele was protective against late virologic breakthrough in patients ...
Besides, correcting the sequence-context effect substantially increases the detection accuracy of the single-locus methods. The threshold of base QV also has a minor impact on the accuracy. A non-zero threshold increases the accuracy on the Bordetella spp. data (Fig. 4a), but decreases the ...
A single gene controlling the response to Ea-1 antigens, which segregates when strains YBR and B10.D2 are crossed, has been shown not to be an allele of theIr-2 locus. A new phenomenon has also been observed in the control of anti-Ea-1 antibody production in that the mating of two...
Most eukaryotes harbor two distinct pre-mRNA splicing machineries: the major spliceosome, which removes >99% of introns, and the minor spliceosome, which removes rare, evolutionarily conserved introns. Although hypothesized to serve important regulato